ArticleHuman brain mapping2020
Cerebral white matter diffusion properties and free-water with obstructive sleep apnea severity in older adults.
Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- White matter microstructural alterations in obstructive sleep apnea assessed by time-dependent diffusion MRI.Japanese journal of radiology · 2026Article
- White matter microstructure differences in obstructive sleep apnea severity groups assessed by diffusion tensor metrics and biophysical modeling.Scientific reports · 2026Article
- Tract-specific white matter changes and their cognitive correlates in obstructive sleep apnea: a cross-sectional study using 3.0 T diffusion tensor imaging.Sleep & breathing = Schlaf & Atmung · 2026Article
- Quantitative study on whole brain volume in patients with obstructive sleep apnea based on synthetic magnetic resonance imaging.BMC medical imaging · 2025Article
- Impaired Topological Architecture of Structural Brain Networks in Obstructive Sleep Apnea: A DTI Study.Nature and science of sleep · 2025Article
- Alteration of multilayer network perspective on gray and white matter connectivity in obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2024Article
- Altered fornix integrity is associated with sleep apnea-related hypoxemia in mild cognitive impairment.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Brain connectivity analysis based classification of obstructive sleep apnea using electroencephalogram signals.Scientific reports · 2024Article
- Cerebrovascular pathology mediates associations between hypoxemia during rapid eye movement sleep and medial temporal lobe structure and function in older adults.bioRxiv : the preprint server for biology · 2024Article
- Microstructural Changes in the Cerebral White Matter After 12 Months of CPAP Treatment for Moderate to Severe Obstructive Sleep Apnoea: A TBSS Study.Nature and science of sleep · 2024Article
- Biophysical modeling and diffusion kurtosis imaging reveal microstructural alterations in normal-appearing white-matter regions of the brain in obstructive sleep apnea.Sleep advances : a journal of the Sleep Research Society · 2024Article
- Daytime Sleepiness, Apnea, Neuroimaging Correlates and Cortisol Dysregulation in a Memory Clinic Cohort.The journal of prevention of Alzheimer's disease · 2024Article
- More extensive white matter disruptions present in untreated obstructive sleep apnea than we thought: A large sample diffusion imaging study.Human brain mapping · 2023Article
- Evaluation of the corpus callosum shape in patients with obstructive sleep apnea.Sleep & breathing = Schlaf & Atmung · 2022Article
- Association of Obstructive Sleep Apnea With White Matter Integrity and Cognitive Performance Over a 4-Year Period in Middle to Late Adulthood.JAMA network open · 2022Article
- Aberrant amplitude of low-frequency fluctuations in different frequency bands and changes after one-night positive airway pressure treatment in severe obstructive sleep apnea.Frontiers in neurology · 2022Article
- Deep Learning-Based Assessment of Brain Connectivity Related to Obstructive Sleep Apnea and Daytime Sleepiness.Nature and science of sleep · 2021Article
- Cerebral white matter diffusion properties and free-water with obstructive sleep apnea severity in older adults.Human brain mapping · 2020Article
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Authors and funding
14 authors at 7 institutions in 2 countries.
Funding
Abstract
Characterizing the effects of obstructive sleep apnea (OSA) on the aging brain could be key in our understanding of neurodegeneration in this population. Our objective was to assess white matter properties in newly diagnosed and untreated adults with mild to severe OSA. Sixty-five adults aged 55 to 85 were recruited and divided into three groups: control (apnea-hypopnea index ≤5/hr; n = 18; 65.2 ± 7.2 years old), mild (>5 to ≤15 hr; n = 27; 64.2 ± 5.3 years old) and moderate to severe OSA (>15/hr; n = 20; 65.2 ± 5.5 years old). Diffusion tensor imaging metrics (fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity, and mean diffusivity) were compared between groups with Tract-Based Spatial Statistics within the white matter skeleton created by the technique. Groups were also compared for white matter hyperintensities volume and the free-water (FW) fraction. Compared with controls, mild OSA participants showed widespread areas of lower diffusivity (p < .05 corrected) and lower FW fraction (p < .05). Participants with moderate to severe OSA showed lower AD in the corpus callosum compared with controls (p < .05 corrected). No between-group differences were observed for FA or white matter hyperintensities. Lower white matter diffusivity metrics is especially marked in mild OSA, suggesting that even the milder form may lead to detrimental outcomes. In moderate to severe OSA, competing pathological responses might have led to partial normalization of diffusion metrics.
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