ArticleHuman brain mapping2020
Putative protective neural mechanisms in prereaders with a family history of dyslexia who subsequently develop typical reading skills.
Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Emerging technologies and neuroscience-based approaches in dyslexia: a narrative review toward integrative and personalized solutions.Frontiers in human neuroscience · 2025Pooled it
- Examination of common and unique brain regions for atypical reading and math: a meta-analysis.Cerebral cortex (New York, N.Y. : 1991) · 2023Pooled it
- Reading intervention and neuroplasticity: A systematic review and meta-analysis of brain changes associated with reading intervention.Neuroscience and biobehavioral reviews · 2022Pooled it
- Does bilingualism buffer genetic predispositions to reading difficulties through alterations of structural interhemispheric connectivity? An ABCDbioRxiv : the preprint server for biology · 2026Article
- Multimodal investigation of the neurocognitive deficits underlying dyslexia in adulthood.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Longitudinal trajectories of brain development from infancy to school age and their relationship with literacy development.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Longitudinal trajectories of brain development from infancy to school age and their relationship to literacy development.bioRxiv : the preprint server for biology · 2025Article
- An approach designed to fail deaf children and their parents and how to change it.Harm reduction journal · 2024Review
- Unraveling individual differences in learning potential: A dynamic framework for the case of reading development.Developmental cognitive neuroscience · 2024Review
- Investigating Dyslexia through Diffusion Tensor Imaging across Ages: A Systematic Review.Brain sciences · 2024Review
- Reflections on the past two decades of Mind, Brain, and Education.Mind, brain and education : the official journal of the International Mind, Brain, and Education Society · 2024Article
- From brain to education through machine learning: Predicting literacy and numeracy skills from neuroimaging data.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- A sculpting effect of reading on later representational quality of phonology revealed by multi-voxel pattern analysis in young children.Brain and language · 2023Article
- Longitudinal changes in brain activation underlying reading fluency.Human brain mapping · 2023Article
- Fiber-specific structural properties relate to reading skills in children and adolescents.eLife · 2022Article
- Patterns of Neural Functional Connectivity in Infants at Familial Risk of Developmental Dyslexia.JAMA network open · 2022Article
- Distinctive neural correlates of phonological and reading impairment in fetal alcohol-exposed adolescents with and without facial dysmorphology.Neuropsychologia · 2022Article
- Brain dynamics of (a)typical reading development-a review of longitudinal studies.NPJ science of learning · 2021Review
- How Learning to Read Changes the Listening Brain.Frontiers in psychology · 2021Review
- Multifactorial pathways facilitate resilience among kindergarteners at risk for dyslexia: A longitudinal behavioral and neuroimaging study.Developmental science · 2021Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Developmental dyslexia affects 40-60% of children with a familial risk (FHD+) compared to a general prevalence of 5-10%. Despite the increased risk, about half of FHD+ children develop typical reading abilities (FHD+Typical). Yet the underlying neural characteristics of favorable reading outcomes in at-risk children remain unknown. Utilizing a retrospective, longitudinal approach, this study examined whether putative protective neural mechanisms can be observed in FHD+Typical at the prereading stage. Functional and structural brain characteristics were examined in 47 FHD+ prereaders who subsequently developed typical (n = 35) or impaired (n = 12) reading abilities and 34 controls (FHD-Typical). Searchlight-based multivariate pattern analyses identified distinct activation patterns during phonological processing between FHD+Typical and FHD-Typical in right inferior frontal gyrus (RIFG) and left temporo-parietal cortex (LTPC) regions. Follow-up analyses on group-specific classification patterns demonstrated LTPC hypoactivation in FHD+Typical compared to FHD-Typical, suggesting this neural characteristic as an FHD+ phenotype. In contrast, RIFG showed hyperactivation in FHD+Typical than FHD-Typical, and its activation pattern was positively correlated with subsequent reading abilities in FHD+ but not controls (FHD-Typical). RIFG hyperactivation in FHD+Typical was further associated with increased interhemispheric functional and structural connectivity. These results suggest that some protective neural mechanisms are already established in FHD+Typical prereaders supporting their typical reading development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.