ArticleMedical physics2020
Dose- rather than fluence-averaged LET should be used as a single-parameter descriptor of proton beam quality for radiochromic film dosimetry.
Article in Medical physics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Critical methodological concerns regarding the validation of NanOx model in helium SOBP irradiation.Physics and imaging in radiation oncology · 2026Article
- Benchmarking Radiochromic EBT4 Film for Clinical Proton DosimetryRadiochromic Films for Proton Dosimetry.International journal of particle therapy · 2026Article
- A review on radiochromic film dosimetry in radiation therapy.Journal of applied clinical medical physics · 2025Review
- Proof of concept for the usability of the IRRAMICE for proton preclinical radiobiological research by a traceable dosimetry evaluation.Scientific reports · 2025Article
- Commissioning of a precision preclinical 200 kV x-ray irradiator based on modular adaptations.Medical physics · 2025Article
- Evaluation of radiochromic formulations for dosimetry in high-energy photon and proton beams.Communications materials · 2025Article
- Effects of modern aesthetic dental fillings on proton therapy.Physics and imaging in radiation oncology · 2024Article
- Comprehensive dosimetric commissioning of proton minibeam radiotherapy on a single gantry proton system.Frontiers in oncology · 2024Article
- Accelerating and improving radiochromic film calibration by utilizing the dose ratio in photon and proton beams.Medical physics · 2022Article
- Improved simultaneous LET and dose measurements in proton therapy.Scientific reports · 2022Article
- Dose calculation accuracy in particle therapy: Comparing carbon ions with protons.Medical physics · 2021Article
- Dual-storage phosphor proton therapy dosimetry: Simultaneous quantification of dose and linear energy transfer.Medical physics · 2021Article
- Empirical quenching correction in radiochromic silicone-based three-dimensional dosimetry of spot-scanning proton therapy.Physics and imaging in radiation oncology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
purposeThe dose response of Gafchromic EBT3 films exposed to proton beams depends on the dose, and additionally on the beam quality, which is often quantified with the linear energy transfer (LET) and, hence, also referred to as LET quenching. Fundamentally different methods to determine correction factors for this LET quenching effect have been reported in literature and a new method using the local proton fluence distribution differential in LET is presented. This method was exploited to investigate whether a more practical correction based on the dose- or fluence-averaged LET is feasible in a variety of clinically possible beam arrangements.
methodsThe relative effectiveness (RE) was characterized within a high LET spread-out Bragg peak (SOBP) in water made up by the six lowest available energies (62.4-67.5 MeV, configuration "
resultsThe uncorrected film dose deviated up to 26% from the reference dose, whereas the corrected film dose agreed within 3% in all three beams in water ("
conclusionsThe film quenching was found to be nonlinear as a function of proton LET as well as of the dose-averaged LET. However, the linear relation of RE on dose-averaged LET was a good approximation in all cases. In contrast to dose-averaged LET, fluence-averaged LET could not describe the RE when multiple beams were applied.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.