Evidence map›Paper›PMID 32166721›Full record

Observational studyLa Radiologia medica2020

Post-mastectomy immediate breast reconstruction and adjuvant radiotherapy: long term results of a mono institutional experience.

Chiara Reverberi, Luca Marinelli, Barbara Campanella, Giovanna Scalabrino, Luca Nicosia, Dimitri Anzellini, Vitaliana De Sanctis, Maurizio Valeriani, Mattia F Osti

Abstract readObservational Study

PubMed Publisher

In one paragraph

Observational study in La Radiologia medica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it

0cells of the map it votes in

8citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

Increasing Rates but Persistent Variability of Immediate Breast Reconstruction: Real-Time Data from a Population-Based Study (2012-2022).Annals of surgical oncology · 2025
Article
Safety and aesthetic outcomes of double purse-string suture nipple reconstruction in early breast cancer patients undergoing nipple resection and endoscopic skin-sparing mastectomy with breast reconstruction.Frontiers in oncology · 2024
Article
Comparison between two packages for pectoral muscle removal on mammographic images.La Radiologia medica · 2022
Article
Oncoplastic Level II Surgical Techniques for Breast Cancer Treatment: Long-Term Outcomes.Breast care (Basel, Switzerland) · 2022
Article
Prognostic effect of radiotherapy in breast cancer patients underwent immediate reconstruction after mastectomy.Frontiers in oncology · 2022
Article
The Impact of Adjuvant Radiotherapy on Immediate Implant-based Breast Reconstruction Surgical and Satisfaction Outcomes: A Systematic Review and Meta-analysis.Plastic and reconstructive surgery. Global open · 2021
Article
Breast cancer patient perspective on opportunities and challenges of a genetic test aimed to predict radio-induced side effects before treatment: Analysis of the Italian branch of the REQUITE project.La Radiologia medica · 2021
Article
Mastectomy with immediate breast reconstruction: Results of a mono-centric 4-years cohort.Annals of medicine and surgery (2012) · 2021
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chiara ReverberiRadiation Oncology Department, Sant'Andrea Hospital, La Sapienza II University of Rome, Via di Grottarossa 1035, Rome, Italy. chiarareverberi87@gmail.com.

Luca MarinelliRadiation Oncology Department, Sant'Andrea Hospital, La Sapienza II University of Rome, Via di Grottarossa 1035, Rome, Italy.

Barbara CampanellaRadiation Oncology Department, Sant'Andrea Hospital, La Sapienza II University of Rome, Via di Grottarossa 1035, Rome, Italy.

Giovanna ScalabrinoRadiation Oncology Department, Sant'Andrea Hospital, La Sapienza II University of Rome, Via di Grottarossa 1035, Rome, Italy.

Luca NicosiaRadiation Oncology Department, IRCCS Sacro Cuore Don Calabria Hospital, Negrar, Verona, Italy.

Dimitri AnzelliniRadiation Oncology Department, Sant'Andrea Hospital, La Sapienza II University of Rome, Via di Grottarossa 1035, Rome, Italy.

Vitaliana De SanctisRadiation Oncology Department, Sant'Andrea Hospital, La Sapienza II University of Rome, Via di Grottarossa 1035, Rome, Italy.

Maurizio ValerianiRadiation Oncology Department, Sant'Andrea Hospital, La Sapienza II University of Rome, Via di Grottarossa 1035, Rome, Italy.

Mattia F OstiRadiation Oncology Department, Sant'Andrea Hospital, La Sapienza II University of Rome, Via di Grottarossa 1035, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe aim of this paper is to investigate the outcome of patients treated with mastectomy, immediate breast reconstruction (IBR) and post-mastectomy radiotherapy (PMRT) and the risk of late complications. MATERIAL AND

methodAll patients had post-mastectomy, immediate reconstructive surgical procedure by using autologous abdominal implant; tissue expander (TE)/permanent prosthesis (PP); or even combined procedures. Adjuvant external beam radiotherapy treatment (EBRT) was delivered to the reconstructed chest wall and supraclavicular nodes, for a total dose of 50 Gy in 25 fractions. The Kaplan-Meyer analysis evaluates patients' rate of late side effects, Overall Survival (OS), Progression Free survival (PFS), Local-regional free survival (LRFS) and Metastasis Free Survival (MFS). The univariate analysis investigates the correlation between late toxicity and related factors.

resultsBetween November 2003 and October 2016, 91 breast cancer patients were treated with IBR and PMRT. Twenty-three (25.3%) patients experimented late toxicity. Overall, 16 (17.6%) patients experienced late complications which required a surgical approach. The 1- 2- 5- years late toxicity rates were 96.6%, 87.1% and 77.9%, respectively. The type of reconstruction was not statistically related with late toxicity rate (P = 0.35). The median follow-up period was 59 months (range 6-142 months). Median OS was not reached, the 1- 2- 5-years OS rates were 100%, 95.4% and 81% respectively.

conclusionThis study underlines that the type of reconstruction does not influence late toxicity rate. Moreover, IBR followed by adjuvant radiotherapy, has showed acceptable late toxicity profile and no influence on OS.

Indexed as

MastectomyRadiotherapy, AdjuvantAdultAgedAnalysis of VarianceBreast ImplantsBreast NeoplasmsFemaleFollow-Up StudiesHumansKaplan-Meier EstimateLymphatic IrradiationMammaplastyMiddle AgedProgression-Free SurvivalRadiotherapy DosageBreast cancerImmediate breast reconstruction (IBR)Late toxicity complicationsPost-mastectomy radiotherapy (PMRT)

Identifiers

PMID32166721

DOI10.1007/s11547-020-01161-7

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.