Evidence map›Paper›PMID 32166711›Full record

ArticleProbiotics and antimicrobial proteins2020

Probiotic Lactobacillus johnsonii BS15 Prevents Memory Dysfunction Induced by Chronic High-Fluorine Intake through Modulating Intestinal Environment and Improving Gut Development.

Ning Sun, Xueqin Ni, Hesong Wang, Jinge Xin, Ying Zhao, Kangcheng Pan, Bo Jing, Dong Zeng

Abstract read
PubMed Publisher
In one paragraph

Article in Probiotics and antimicrobial proteins, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Frontiers in microbiology · 2025
    Article
  6. Unveiling the potential ofFrontiers in microbiology · 2025
    Review
  7. Article
  8. Gut microbial metabolism in Alzheimer's disease and related dementias.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
    Review
  9. Gut · 2024
    Article
  10. Article
  11. Preventive effect ofFrontiers in microbiology · 2024
    Article
  12. The Effects ofMicroorganisms · 2023
    Review
  13. Development and Applications of CRISPR/Cas9-Based Genome Editing inInternational journal of molecular sciences · 2022
    Review
  14. Frontiers in immunology · 2022
    Article
  15. Psychoactive Effects ofFrontiers in microbiology · 2022
    Article
  16. Article
  17. Psychoactive Effects ofFrontiers in pharmacology · 2021
    Article
  18. Frontiers in microbiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ning SunAnimal Microecology Institute, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China.
Xueqin NiAnimal Microecology Institute, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China.
Hesong WangDepartment of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China. sunasa1030@foxmail.com.
Jinge XinAnimal Microecology Institute, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China.
Ying ZhaoAnimal Microecology Institute, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China.
Kangcheng PanAnimal Microecology Institute, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China.
Bo JingAnimal Microecology Institute, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China.
Dong ZengAnimal Microecology Institute, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China. zend@sicau.edu.cn.ORCID 0000-0002-9766-545X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, the influence of chronic fluorosis on the brain has been widely reported. Our study aimed to demonstrate the potential mechanism underlying the impairment of memory function by excessive fluorine intake. We also evaluated whether improvement of intestinal microflora could be a potential therapy to prevent the negative influences from the perspective of gut-brain axis. Male ICR mice were randomly divided into three groups and administered with either phosphate buffered saline (PBS) (Control and F groups) or Lactobacillus johnsonii BS15 (FP group; daily amounts of 1 × 10

Indexed as

AmnesiaAnimalsAvoidance LearningCariostatic AgentsCatalaseDisease Models, AnimalGastrointestinal MicrobiomeGene Expression RegulationGlutathione ReductaseHippocampusIntestine, SmallLactobacillus johnsoniiMaleMiceMice, Inbred ICRMicrotubule-Associated ProteinsCariostatic AgentsCatalaseGlutathione ReductaseMicrotubule-Associated ProteinsMtap2 protein, mouseReceptors, N-Methyl-D-AspartateSodium FluorideSuperoxide DismutaseSynaptophysinSyp protein, mouseFluorosisGut-brain axisMemory impairmentProbioticPsychological stress

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.