Evidence map›Paper›PMID 32166698›Full record

ArticleJournal of endocrinological investigation2020

The role of androgen receptor CAG repeat polymorphism in androgen excess disorder and idiopathic hirsutism.

S Polat, S Karaburgu, K Unluhizarci, M Dündar, Y Özkul, Y K Arslan, Z Karaca, F Kelestimur

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Journal of endocrinological investigation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05157373 (The Effect of Androgen Receptor Polymorphism on Endometrial Cancer Development, Progression, and Outcome), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05157373 unknown statusnot on this mapstarted 2022, after this paper: background citation

The Effect of Androgen Receptor Polymorphism on Endometrial Cancer Development, Progression, and Outcome

TypeobservationalSponsorUniversity of NicosiaRan2022 to 2024Enrolled150ConditionsAndrogen Receptor Abnormal, Endometrial DisorderArmsEndometrial sampling and Peripheral blood collection, FSFI Scale
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Hirsutism, Normal Androgens and Diagnosis of PCOS.Diagnostics (Basel, Switzerland) · 2022
    Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

S PolatDepartment of Medical Genetics, Medical Faculty, Erzincan University, Basbaglar Mah, 24100, Erzincan, Merkez, Turkey. polatdna@yahoo.com.
S KaraburguDepartment of Endocrinology, Medical Faculty, Erciyes University, Kayseri, Turkey.
K UnluhizarciDepartment of Endocrinology, Medical Faculty, Erciyes University, Kayseri, Turkey.
M DündarDepartment of Medical Genetics, Medical Faculty, Erciyes University, Kayseri, Turkey.
Y ÖzkulDepartment of Medical Genetics, Medical Faculty, Erciyes University, Kayseri, Turkey.
Y K ArslanDepartment of Biostatistics, Medical Faculty, Erzincan University, Erzincan, Turkey.
Z KaracaDepartment of Endocrinology, Medical Faculty, Erciyes University, Kayseri, Turkey.
F KelestimurDepartment of Endocrinology, Medical Faculty, Erciyes University, Kayseri, Turkey.
Erciyes University · TRErzincan Binali Yıldırım University · TRYeditepe University · TR

Funding

Erciyes Üniversitesi (TR) TDK-2014-5099
6 · The paper itself

Abstract

purposeThe study aimed to investigate whether repeat number in the androgen receptor (AR) gene has any contribution to phenotypes of the disease of androgen excess (polycystic ovary syndrome (PCOS), idiopathic hyperandrogenemia (IHA) and idiopathic hirsutism (IH) in a cohort of Turkish women.

methodsThree hundred and fifty-four voluntary premenopausal women (172 healthy controls and 182 patients with androgen excess disorders and idiopathic hirsutism) 18-45 years of age seen at an outpatient endocrine clinic at Erciyes University Hospital between January 2013 and December 2014 were included. All volunteers have undergone physical examination and biochemical evaluation. The polymorphic (CAG)n repeat of the human AR was determined by fragment analyses.

resultsDetailed clinical analyses of the patients ended up with 137 PCOS, 24 IHA, and 21 IH. Pairwise comparisons revealed the CAG repeat number differences between the PCOS and controls (p = 0.005) and IH and controls (p = 0.020). Women with CAG repeat length ≤ 17 had a significantly increased twofold risk for PCOS than those women with > 17 CAG repeats OR: 2.0 (95% CI 1.2-3.3, p = 0.005). Women with CAG repeat length ≤ 17 had a significantly increased threefold risk for IH than those women with > 17 CAG repeats OR: 2.9 (95% CI 1.2-7.3, p = 0.020). When correlation analysis was performed, a weak negative correlation was detected between the short allele and FGS score (r = - 0.131, p = 0.013) and a positive relationship between total testosterone and longer allele in the IHA group (r = 0.425, p = 0.039). Median repeat length of the shorter allele between oligomenorrhea and woman with normal menstrual cycle was found to be statistically significant (p = 0.017).

conclusionThis study indicated that the risk of PCOS and IH is associated with the inheritance of ARs with shorter CAG repeats.

Indexed as

AdolescentAdultCase-Control StudiesCohort StudiesFemaleGenetic Association StudiesGenetic Predisposition to DiseaseHirsutismHumansHyperandrogenismMiddle AgedPhenotypePolycystic Ovary SyndromePolymorphism, GeneticReceptors, AndrogenTestosteroneAR protein, humanReceptors, AndrogenTestosteroneAndrogen excessAndrogen receptorHirsutismPolymorphism

Identifiers

PMID32166698
OpenAlexW3012269387

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.