ArticleCurrent medical science2020
Network Pharmacology-based Research of Active Components of Albiziae Flos and Mechanisms of Its Antidepressant Effect.
Article in Current medical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
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- Research progress on plant-derived bioactive compounds and late-life depression: from neuroprotective mechanisms to dietary patterns.Frontiers in nutrition · 2026Review
- Erchen Decoction Offers Health Benefits in Regulating Obesity: Component Analysis, Network Pharmacology, and Experiment Verification.Food science & nutrition · 2025Article
- Mechanisms of a Patented Chinese Herbal Medicine for Treating Hypothyroidism inCurrent pharmaceutical design · 2025Article
- Elucidating the mechanism of stigmasterol in acute pancreatitis treatment: insights from network pharmacology andFrontiers in pharmacology · 2024Article
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- Exploring the Mechanism of Action ofComputational and mathematical methods in medicine · 2022Article
- Effects of quercetin on the alterations of serum elements in chronic unpredictable mild stress-induced depressed rats.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2021Article
- A Network Pharmacology Study to Uncover the Multiple Molecular Mechanism of the Chinese Patent Medicine Toujiequwen Granules in the Treatment of Corona Virus Disease 2019 (COVID-19).Current medical science · 2021Article
- Quercitrin Attenuates Acetaminophen-Induced Acute Liver Injury by Maintaining Mitochondrial Complex I Activity.Frontiers in pharmacology · 2021Article
- Jie-Yu-He-Huan Capsule Ameliorates Anxiety-Like Behaviours in Rats Exposed to Chronic Restraint Stress via the cAMP/PKA/CREB/BDNF Signalling Pathway.Oxidative medicine and cellular longevity · 2021Article
- Network Pharmacology and Molecular Docking Analyses of Mechanisms Underlying Effects of theEvidence-based complementary and alternative medicine : eCAM · 2021Article
- Integrated Metabolomics and Network Pharmacology to Establish the Action Mechanism of Qingrekasen Granule for Treating Nephrotic Syndrome.Frontiers in pharmacology · 2021Article
- An Integrative Pharmacology-Based Pattern to Uncover the Pharmacological Mechanism of Ginsenoside H Dripping Pills in the Treatment of Depression.Frontiers in pharmacology · 2020Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Albiziae Flos (AF) has been experimentally proven to have an antidepressant effect. However, due to the complexity of botanical ingredients, the exact pharmacological mechanism of action of AF in depression has not been completely deciphered. This study used the network pharmacology method to construct a component-target-pathway network to explore the active components and potential mechanisms of action of AF. The methods included collection and screening of chemical components, prediction of depression-associated targets of the active components, gene enrichment, and network construction and analysis. Quercetin and 4 other active components were found to exert antidepressant effects mainly via monoaminergic neurotransmitters and cAMP signaling and neuroactive ligand-receptor interaction pathways. DRD2, HTR1A, and SLC6A4 were identified as important targets of the studied bioactive components of AF. This network pharmacology analysis provides guidance for further study of the antidepressant mechanism of AF.
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