Evidence map›Paper›PMID 32166646›Full record

ArticleDrugs in R&D2020

Concordance of Vancomycin Population-Predicted Pharmacokinetics with Patient-Specific Pharmacokinetics in Adult Hospitalized Patients: A Case Series.

IfeanyiChukwu O Onor, Alison Neuliep, Kieu Anh Tran, Jennifer Lambert, Christopher J Gillard, Fatima Brakta, Michael C Ezebuenyi, Kirbie St James, John I Okogbaa, Robbie A Beyl

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drugs in R&D, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

IfeanyiChukwu O OnorCollege of Pharmacy, Xavier University of Louisiana, 1 Drexel Drive, Box COP, New Orleans, LA, 70125, USA. ionor@xula.edu.
Alison NeuliepCollege of Pharmacy, Xavier University of Louisiana, 1 Drexel Drive, Box COP, New Orleans, LA, 70125, USA.
Kieu Anh TranCollege of Pharmacy, Xavier University of Louisiana, 1 Drexel Drive, Box COP, New Orleans, LA, 70125, USA.
Jennifer LambertDepartment of Pharmacy, University Medical Center New Orleans, 2000 Canal Street, New Orleans, LA, 70112, USA.
Christopher J GillardCollege of Pharmacy, Xavier University of Louisiana, 1 Drexel Drive, Box COP, New Orleans, LA, 70125, USA.
Fatima BraktaDepartment of Medicine, Louisiana State University Health Sciences Center School of Medicine, 1542 Tulane Avenue, New Orleans, LA, 70112, USA.
Michael C EzebuenyiDepartment of Pharmacy, Our Lady of the Lake Regional Medical Center, 5000 Hennessy Boulevard, Baton Rouge, LA, 70808, USA.
Kirbie St JamesDepartment of Pharmacy, University Medical Center New Orleans, 2000 Canal Street, New Orleans, LA, 70112, USA.
John I OkogbaaCollege of Pharmacy, Xavier University of Louisiana, 1 Drexel Drive, Box COP, New Orleans, LA, 70125, USA.
Robbie A BeylPennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.
University of New Orleans · USXavier University of Louisiana · USUniversity Medical Center New Orleans · USOur Lady of the Lake Regional Medical Center · USPennington Biomedical Research Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVancomycin empiric therapy is commonly dosed using clinical algorithms adapted from population-predicted pharmacokinetic parameters. However, precise dosing of vancomycin can be designed using patient-specific pharmacokinetic calculations.

objectiveThe objective of this study is to assess the correlational fit between vancomycin population-predicted and patient-specific pharmacokinetic parameters [elimination rate constant (K

methodsThis is a single-center case series of hospitalized adult patients who received vancomycin, had creatinine clearance calculation for derivation of population-predicted pharmacokinetic parameters, and had two vancomycin concentrations for calculation of patient-specific pharmacokinetic parameters. The primary objective of this case series is to evaluate the correlation between population-predicted and patient-specific pharmacokinetic parameters. The secondary objectives of this study are to evaluate the mean bias and precision between the population-predicted and patient-specific pharmacokinetic parameters and to assess the correlation between population-predicted and patient-specific pharmacokinetic parameters in special population subgroups (obese patients with body mass index ≥ 30 kg/m

resultsA total of 30 patients were included in the study; 33.3% (10/30) of the patients were obese and 56.7% (17/30) had renal dysfunction. In all patients in the study, the calculated population-predicted K

conclusionsIn this case series, population-predicted pharmacokinetic parameters were strongly correlated with patient-specific pharmacokinetic parameters. The vancomycin population-predicted pharmacokinetic formula can be used safely to predict a patient's vancomycin pharmacokinetic disposition and can be maintained as an empiric dosing strategy in various hospitalized adult patients.

Indexed as

AdultAgedAlgorithmsAnti-Bacterial AgentsDose-Response Relationship, DrugFemaleHospitalizationHumansMaleMiddle AgedVancomycinAnti-Bacterial AgentsVancomycin

Identifiers

PMID32166646
PMCPMC7221031
OpenAlexW3010950384

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.