Evidence map›Paper›PMID 32166562›Full record

ArticleBiological trace element research2020

Organ Metallome Processed with Chemometric Methods Enable the Determination of Elements that May Serve as Markers of Exposure to Iron Oxide Nanoparticles in Male Rats.

Marzena Rugiel, Agnieszka Drozdz, Katarzyna Matusiak, Zuzanna Setkowicz, Krzysztof Klodowski, Joanna Chwiej

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological trace element research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marzena RugielFaculty of Physics and Applied Computer Science, AGH University of Science and Technology, Krakow, Poland.ORCID https://orcid.org/0000-0001-5999-356X
Agnieszka DrozdzFaculty of Physics and Applied Computer Science, AGH University of Science and Technology, Krakow, Poland.ORCID https://orcid.org/0000-0002-4604-4557
Katarzyna MatusiakFaculty of Physics and Applied Computer Science, AGH University of Science and Technology, Krakow, Poland.ORCID https://orcid.org/0000-0003-2211-8432
Zuzanna SetkowiczJagiellonian University, Institute of Zoology and Biomedical Research, Krakow, Poland.ORCID https://orcid.org/0000-0002-7213-8194
Krzysztof KlodowskiFaculty of Physics and Applied Computer Science, AGH University of Science and Technology, Krakow, Poland.ORCID https://orcid.org/0000-0002-0880-5175
Joanna ChwiejFaculty of Physics and Applied Computer Science, AGH University of Science and Technology, Krakow, Poland. joanna.chwiej@fis.agh.edu.pl.ORCID https://orcid.org/0000-0002-3792-7876

Funding

Ministry of Science and Higher Education 11.11.220.01/3
6 · The paper itself

Abstract

The systemic influence of iron oxide nanoparticles on the elemental homeostasis of key organs was examined in male rats. In tissues taken at different intervals from nanoparticles injection, the dynamics of elemental changes was analyzed. The organ metallome was studied using total reflection X-ray fluorescence. The obtained data were processed with advanced cluster and discriminant analyses-to classify the tissues according to their organs of origin and to distinguish accurately the nanoparticle-treated and normal rats. Additionally, in the case of liver and heart, it was possible to determine the elements of highest significance for different treatments, which may serve as markers of exposure to iron oxide nanoparticles.

Indexed as

Magnetic Iron Oxide NanoparticlesNanoparticlesAnimalsBiomarkersLiverMaleRatsBiomarkersCluster and discriminant analysisElemental analysisIron oxide nanoparticlesMultivariate methodsTotal reflection X-ray fluorescence microscopy

Identifiers

PMID32166562
PMCPMC7561579

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.