Evidence map›Paper›PMID 32166471›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2020

Discovering the Italian phenotype of cerebral amyloid angiopathy (CAA): the SENECA project.

Anna Bersano, Emma Scelzo, Leonardo Pantoni, Andrea Morotti, Alessandra Erbetta, Luisa Chiapparini, Paolo Vitali, Giorgio Giaccone, Paola Caroppo, Marcella Catania and 23 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 7 citations in OpenAlex.

  1. Observational
  2. Article
  3. Observational
  4. Observational
  5. Article
  6. Authors' reply to Bugiani O: More focus on SENECA with CAA.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Article
  7. More focus on SENECA with CAA.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021
    Article
  8. Understanding the Pathophysiology of Cerebral Amyloid Angiopathy.International journal of molecular sciences · 2020
    Review
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

33 authors at 15 institutions in 3 countries.

Anna BersanoCerebrovascular Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy. anna.bersano@gmail.com.ORCID http://orcid.org/0000-0002-2493-628X
Emma ScelzoCerebrovascular Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Leonardo Pantoni"Luigi Sacco" Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.
Andrea MorottiStroke Unit, IRCCS Foundation Neurological Institute C. Mondino, Pavia, Italy.
Alessandra ErbettaNeuroradiology Department, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Luisa ChiappariniNeuroradiology Department, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Paolo VitaliNeuroradiology Unit, Policlinico San Donato, Milan, Italy.
Giorgio GiacconeUnit of Neurology 5 and Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Paola CaroppoUnit of Neurology 5 and Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Marcella CataniaUnit of Neurology 5 and Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Laura ObiciAmyloidosis Research and Treatment Centre, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Giuseppe Di FedeUnit of Neurology 5 and Neuropathology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Laura GattiNeurobiology Laboratory, Cerebrovascular Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Francesca TinelliNeurobiology Laboratory, Cerebrovascular Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Jacopo C Di FrancescoDepartment of Neurology, Milan Center for Neuroscience, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy.
Fabrizio PiazzaMilan Center for Neuroscience, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.
Carlo FerrareseDepartment of Neurology, Milan Center for Neuroscience, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy.
Massimo GaspariniDepartment of Nuclear Medicine, IRCCS MultiMedica Sesto San Giovanni, Milan, Italy.
Laura AdobbatiStroke Unit, Istituto Auxologico Italiano IRCCS, Milan, Italy.
Stefania Bianchi-MarzoliNeuro-ophthalmology Center and Electrophysiology Laboratory, Scientific Institute Capitanio Hospital, Istituto Auxologico Italiano IRCCS, Milan, Italy.
Gemma TremoladaNeuro-ophthalmology Center and Electrophysiology Laboratory, Scientific Institute Capitanio Hospital, Istituto Auxologico Italiano IRCCS, Milan, Italy.
Simona SaccoNeuroscience Section, Department of Applied Clinical Science and Biotechnology, University of L'Aquila, L'Aquila, Italy.
Michelangelo MancusoDepartment of Clinical and Experimental Medicine, Neurological Institute, University of Pisa, Pisa, Italy.
Maria Luisa ZeddeNeurology Unit, Stroke Unit, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Massimiliano GodaniDepartment of Neurology, S. Andrea Hospital, La Spezia, Italy.
Silvia LanfranconiDepartment of Neuroscience, Neurology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Davide PareysonUnit of Rare Neurodegenerative and Neurometabolic Diseases, Department of Clinical Neurosciences, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Marco Di GirolamoClinical Pathophysiology Center, AFaR Foundation, 'San Giovanni Calibita' Fatebenefratelli Hospital, Rome, Italy.
Cristina MottoStroke Unit, Niguarda Ca' Granda Hospital, Milan, Italy.
Andreas CharidimouHemorrhagic Stroke Research Program, J. Philip Kistler Stroke Research Center, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Gregoire BoulouisNeuroradiology Department, Paris Descartes University, INSERM U1266, DHU Neurovasculaire, Sainte-Anne Hospital, Paris, France.
Eugenio A ParatiCerebrovascular Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
SENECA project
Fondazione IRCCS Istituto Neurologico Carlo Besta · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITHarvard University · USIRCCS Istituto Auxologico Italiano · ITIRCCS Policlinico San Donato · ITMultiMedica · ITPoliclinico San Matteo Fondazione · ITUniversity of Milan · ITUniversity of Milano-Bicocca · ITUniversity of Pisa · ITAzienda Sanitaria Unità Locale di Reggio Emilia · ITAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · ITFatebenefratelli Hospital · ITInserm · FRUniversity of L'Aquila · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral amyloid angiopathy (CAA) is one of the major types of cerebral small vessel disease, and a leading cause of spontaneous intracerebral hemorrhage and cognitive decline in elderly patients. Although increasingly detected, a number of aspects including the pathophysiology, the clinical and neuroradiological phenotype, and the disease course are still under investigation. The incomplete knowledge of the disease limits the implementation of evidence-based guidelines on patient's clinical management and the development of treatments able to prevent or reduce disease progression. The SENECA (SEarchiNg biomarkErs of Cerebral Angiopathy) project is the first Italian multicenter cohort study aimed at better defining the disease natural history and identifying clinical and neuroradiological markers of disease progression. By a multidisciplinary approach and the collection of a large and well-phenotyped series and biorepository of CAA patients, the study is ultimately expected to improve the diagnosis and the knowledge of CAA pathophysiological mechanisms.

Indexed as

Cerebral Amyloid AngiopathyAgedCerebral HemorrhageCohort StudiesHumansItalyMagnetic Resonance ImagingPhenotypeBiomarkersCerebral amyloid angiopathyCortical superficial siderosisDementiaIntracerebral hemorrhageMicrobleedsNeuroimagingSmall vessel disease

Identifiers

PMID32166471
OpenAlexW3012398066

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.