Evidence map›Paper›PMID 32166456›Full record

ArticleBulletin of mathematical biology2020

Complex Far-Field Geometries Determine the Stability of Solid Tumor Growth with Chemotaxis.

Min-Jhe Lu, Chun Liu, John Lowengrub, Shuwang Li

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bulletin of mathematical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Min-Jhe LuDepartment of Applied Mathematics, Illinois Institute of Technology, Chicago, IL, 60616, USA.
Chun LiuDepartment of Applied Mathematics, Illinois Institute of Technology, Chicago, IL, 60616, USA.
John LowengrubDepartments of Mathematics and Biomedical Engineering, Center for Complex Biological Systems, Chao Family Comprehensive Cancer Center, University of California at Irvine, Irvine, CA, 92617, USA. lowengrb@math.uci.edu.
Shuwang LiDepartment of Applied Mathematics, Illinois Institute of Technology, Chicago, IL, 60616, USA. sli@math.iit.edu.ORCID 0000-0002-4982-6650
Illinois Institute of Technology · USIIT Research Institute · USUniversity of California, Irvine · US

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Christine Hui · 1994 to 2026
$57.9M
Shared Resource Core: Single Cell AnalysisU54CA217378 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI VAN ETTEN, RICHARD A. · 2018 to 2022
$9.7M
National Science Foundation 1720420National Science Foundation 1759536National Science Foundation 1763272NCI NIH HHS P30 CA062203NCI NIH HHS U54 CA217378
6 · The paper itself

Abstract

In this paper, we develop a sharp interface tumor growth model to study the effect of the tumor microenvironment using a complex far-field geometry that mimics a heterogeneous distribution of vasculature. Together with different nutrient uptake rates inside and outside the tumor, this introduces variability in spatial diffusion gradients. Linear stability analysis suggests that the uptake rate in the tumor microenvironment, together with chemotaxis, may induce unstable growth, especially when the nutrient gradients are large. We investigate the fully nonlinear dynamics using a spectrally accurate boundary integral method. Our nonlinear simulations reveal that vascular heterogeneity plays an important role in the development of morphological instabilities that range from fingering and chain-like morphologies to compact, plate-like shapes in two dimensions.

Indexed as

Models, BiologicalApoptosisBiological Transport, ActiveCell ProliferationChemotaxisComputer SimulationHumansLinear ModelsMathematical ConceptsNeoplasm InvasivenessNeoplasmsNonlinear DynamicsNutrientsTumor MicroenvironmentNutrientsAvascular tumor growthBoundary integral methodChemotaxisComplex geometriesDarcy’s lawSharp interface modelTwo-phase nutrient field

Identifiers

PMID32166456
PMCPMC8445073
OpenAlexW2995962655

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.