Evidence map›Paper›PMID 32166394›Full record

ArticleCellular and molecular life sciences : CMLS2020

Single-cell gene profiling and lineage tracing analyses revealed novel mechanisms of endothelial repair by progenitors.

Jiacheng Deng, Zhichao Ni, Wenduo Gu, Qishan Chen, Witold Norbert Nowak, Ting Chen, Shirin Issa Bhaloo, Zhongyi Zhang, Yanhua Hu, Bin Zhou and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Stem cell antigen-1Cellular and molecular life sciences : CMLS · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. CD34Cellular and molecular life sciences : CMLS · 2022
    Article
  9. Article
  10. Article
  11. Article
  12. Vascular Stem/Progenitor Cells in Vessel Injury and Repair.Frontiers in cardiovascular medicine · 2022
    Review
  13. Setd4 controlled quiescent c-KitScientific reports · 2021
    Article
  14. Article
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Jiacheng DengDepartment of Cardiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, 310003, Zhejiang, China.
Zhichao NiSchool of Cardiovascular Medicine and Science, BHF Centre, King's College London, 125 Coldharbour Lane, London, SE5 9NU, UK.
Wenduo GuSchool of Cardiovascular Medicine and Science, BHF Centre, King's College London, 125 Coldharbour Lane, London, SE5 9NU, UK.
Qishan ChenDepartment of Cardiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, 310003, Zhejiang, China.
Witold Norbert NowakSchool of Cardiovascular Medicine and Science, BHF Centre, King's College London, 125 Coldharbour Lane, London, SE5 9NU, UK.
Ting ChenDepartment of Cardiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, 310003, Zhejiang, China.
Shirin Issa BhalooSchool of Cardiovascular Medicine and Science, BHF Centre, King's College London, 125 Coldharbour Lane, London, SE5 9NU, UK.
Zhongyi ZhangSchool of Cardiovascular Medicine and Science, BHF Centre, King's College London, 125 Coldharbour Lane, London, SE5 9NU, UK.
Yanhua HuSchool of Cardiovascular Medicine and Science, BHF Centre, King's College London, 125 Coldharbour Lane, London, SE5 9NU, UK.
Bin ZhouState Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academic of Sciences, Shanghai, 200031, China.
Li ZhangDepartment of Cardiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, 310003, Zhejiang, China. li_zhang@zju.edu.cn.
Qingbo XuDepartment of Cardiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, 310003, Zhejiang, China. qingbo_xu@zju.edu.cn.ORCID http://orcid.org/0000-0003-2474-8155
King's College London · GBZhejiang University · CNFirst Affiliated Hospital Zhejiang University · CNShanghai Institutes for Biological Sciences · CN

Funding

British Heart Foundation RG/14/6/31144National Natural Science Foundation of China 31830039National Natural Science Foundation of China 81220108004National Natural Science Foundation of China 81570249National Natural Science Foundation of China 91339102National Natural Science Foundation of China 91539103National Natural Science Foundation of China 91639302Royal Society-Newton Advanced Fellowship NA170109
6 · The paper itself

Abstract

Stem/progenitor cells (SPCs) have been implicated to participate in vascular repair. However, the exact role of SPCs in endothelial repair of large vessels still remains controversial. This study aimed to delineate the cellular heterogeneity and possible functional role of endogenous vascular SPCs in large vessels. Using single-cell RNA-sequencing (scRNA-seq) and genetic lineage tracing mouse models, we uncovered the cellular heterogeneity of SPCs, i.e., c-Kit

Indexed as

AnimalsAortaCell DifferentiationCell LineageEndothelial CellsEndothelium, VascularHumansMiceProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-kitRNA-SeqSingle-Cell AnalysisStem CellsTOR Serine-Threonine KinasesProto-Oncogene Proteins c-aktProto-Oncogene Proteins c-kitTOR Serine-Threonine KinasesEndothelial repairLineage tracingMetabolismSingle-cell RNA-sequencingStem cells

Identifiers

PMID32166394
PMCPMC11104897
OpenAlexW3012389947

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.