Evidence map›Paper›PMID 32166378›Full record

ArticleMikrochimica acta2020

"French fries"-like luminescent metal organic frameworks for the fluorescence determination of cytochrome c released by apoptotic cells and screening of anticancer drug activity.

Ruirui Xie, Yanyan Liu, Peipei Yang, Lan Huang, Xun Zou, Jiamin Liu, Qingfan Ren, Jia Tao, Peng Zhao

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Ruirui XieGuangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Yanyan LiuGuangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Peipei YangSchool of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510641, Guangdong, China.
Lan HuangGuangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Xun ZouGuangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Jiamin LiuGuangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, Guangdong, China.
Qingfan RenSchool of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510641, Guangdong, China.
Jia TaoSchool of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510641, Guangdong, China. cejtao@scut.edu.cn.
Peng ZhaoGuangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, Guangdong, China. smuzp@smu.edu.cn.ORCID http://orcid.org/0000-0003-4377-1035
Southern Medical University · CNSouth China University of Technology · CNGuangdong Pharmaceutical University · CNGuangdong University of Technology · CN

Funding

Natural Science Foundation of China 21705050
6 · The paper itself

Abstract

A luminescent metal organic framework was prepared by encapsulating Zn-Ag-In-S quantum dots into "French fries"-like MIL-68(In) metal organic frameworks (ZAISQDs@MIL-68(In)). The ZAISQDs@MIL-68(In) had a maximum excitation wavelength at 370 nm and maximum emission wavelength at 620 nm. It was found that the ZAISQDs@MIL-68(In) was efficiently quenched by cytochrome c (Cyt c), which is an important biomarker of early cell apoptosis. The quenching mechanism was ascribed to be an inner filter effect and dynamic quenching of Cyt c towards the ZAISQDs@MIL-68(In), and the enrichment effect of MIL-68(In). Benefiting from the multiple advantages, ZAISQDs@MIL-68(In) was developed as an assay strategy of Cyt c with logarithmic relation between signal quenching and concentration in the range 0.02 to 3.5 μM. The linear equation was (F

Indexed as

ApoptosisFluorescenceAntineoplastic AgentsCytochromes cDrug Evaluation, PreclinicalHeLa CellsHumansLuminescent AgentsMetal-Organic FrameworksMolecular StructureTumor Cells, CulturedAntineoplastic AgentsCytochromes cLuminescent AgentsMetal-Organic FrameworksAnticancer drugApoptosisCytochrome cFluorescenceMetal organic frameworkQuantum dots

Identifiers

PMID32166378
OpenAlexW3012271380

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.