Evidence map›Paper›PMID 32166345›Full record

ArticleExperimental brain research2020

Long-term potentiation enhancing effect of epileptic insult in the CA1 area is dependent on prior-application of primed-burst stimulation.

Masoumeh Gholami, Narges Hosseinmardi, Javad Mirnajafi-Zadeh, Mohamad Javan, Saeed Semnanian, Nasser Naghdi, Yaghoub Fathollahi

Abstract read
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In one paragraph

Article in Experimental brain research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Masoumeh GholamiDepartment of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, P.O. Box: 14115-111, Tehran, Iran.
Narges HosseinmardiDepartment of Physiology, Medical School, Shaheed Beheshti University of Medical Sciences, Tehran, Iran.
Javad Mirnajafi-ZadehDepartment of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, P.O. Box: 14115-111, Tehran, Iran.
Mohamad JavanDepartment of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, P.O. Box: 14115-111, Tehran, Iran.
Saeed SemnanianDepartment of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, P.O. Box: 14115-111, Tehran, Iran.
Nasser NaghdiDepartment of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran.
Yaghoub FathollahiDepartment of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, P.O. Box: 14115-111, Tehran, Iran. fatolahi@modares.ac.ir.ORCID http://orcid.org/0000-0002-3695-4805
Tarbiat Modares University · IRPasteur Institute of Iran · IRShahid Beheshti University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herein field recordings were utilized to test the effects of a transient period of pentylenetetrazol (PTZ) treatment on theta-burst long-term potentiation (LTP) at the Schaffer collateral-CA1 synapses as well as RT-PCR was used to investigate the effects of the combination of the pharmacological treatment and the theta-burst LTP induction on the expression of NMDA subunit mRNA in hippocampal slices. The slope of field excitatory postsynaptic potential (fEPSP) was unaffected while the population spike amplitude and area were increased by a transient period of PTZ treatment (3 mM, 10 min). After a theta burst, a brief PTZ exposure can lead to an enhancement of LTP as documented by fEPSP recording. The effect can be blocked by a selective NMDA receptor antagonist DL-AP5. An increase in the expression of GluN2B and GluN2A subunit mRNAs was also shown due to the combined treatment. The results indicate that the combined treatment increases the degree of NMDA-dependent LTP and are in accord with literature data on the subunit alterations of the hippocampal NMDA receptors. Moreover, our experimental paradigm can be used as a new approach to study the relevance of LTP-like phenomena and epileptic mechanisms.

Indexed as

CA1 Region, HippocampalEpilepsyExcitatory Postsynaptic PotentialsLong-Term PotentiationTranscranial Magnetic StimulationAnimalsDisease Models, AnimalExcitatory Amino Acid AntagonistsGABA AntagonistsMalePentylenetetrazoleRats, WistarReceptors, N-Methyl-D-AspartateRNA, MessengerExcitatory Amino Acid AntagonistsGABA AntagonistsNR2B NMDA receptorPentylenetetrazoleReceptors, N-Methyl-D-AspartateRNA, MessengerHybrid protocolLong-term potentiationNMDA receptorSynaptic plasticity

Identifiers

PMID32166345
OpenAlexW3010981459

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.