Evidence map›Paper›PMID 32166211›Full record

ArticleEnvironmental epidemiology (Philadelphia, Pa.)2019

A case-control study of breast cancer risk and ambient exposure to pesticides.

Carrie Tayour, Beate Ritz, Bryan Langholz, Paul K Mills, Anna Wu, John P Wilson, Kaveh Shahabi, Myles Cockburn

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental epidemiology (Philadelphia, Pa.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. The use of pesticides in Polish agriculture after integrated pest management (IPM) implementation.Environmental science and pollution research international · 2021
    Article
  18. Endocrine-disrupting chemicals: implications for human health.The lancet. Diabetes & endocrinology · 2020
    Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Carrie TayourDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
Beate RitzDepartments of Epidemiology and Environmental Sciences, Fielding School of Public Health, University of California, Los Angeles, California.
Bryan LangholzDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
Paul K MillsDepartment of Medicine, University of California, San Francisco, Fresno, California.
Anna WuDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
John P WilsonSpatial Sciences Institute, University of Southern California, Los Angeles, California.
Kaveh ShahabiSpatial Sciences Institute, University of Southern California, Los Angeles, California.
Myles CockburnDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
University of Southern California · USUniversity of California, Los Angeles · USUniversity of California, San Francisco · US

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Joseph Leo Wiemels · 1996 to 2026
$46.4M
NIEHS NIH HHS P30 ES007048
6 · The paper itself

Abstract

While the estrogenic properties of certain pesticides have been established, associations between pesticide exposure and risk of breast cancer have been inconsistently observed. We investigated the relation between pesticide exposure and breast cancer risk using methods capable of objectively assessing exposure to specific pesticides occurring decades before diagnosis.

methodsA case-control study was conducted to evaluate the risk of postmenopausal breast cancer associated with historic pesticide exposure in California's Central Valley, the most agriculturally productive region in the United States where pesticide drift poses a major source of nonoccupational exposure. Residential and occupational histories were linked to commercial pesticide reports and land use data to determine exposure to specific chemicals. Cases (N = 155) were recruited from a population-based cancer registry, and controls (N = 150) were obtained from tax assessor and Medicare list mailings.

resultsThere was no association between breast cancer and exposure to a selected group of organochlorine pesticides thought to have synergistic endocrine-disrupting potential; however, breast cancer was three times as likely to occur among women exposed to chlorpyrifos compared with those not exposed, after adjusting for exposure to other pesticides including organochlorines (OR = 3.22; 95% CI = 1.38, 7.53).

conclusionsOrganophosphate pesticides, such as chlorpyrifos, have rarely been evaluated in studies of breast cancer risk. Additional research is needed to confirm these findings and to better understand the underlying mechanisms given that chlorpyrifos has been detected in local air monitoring at levels of concern for residents living in the agricultural regions where it is used.

Indexed as

Breast cancerExposure AssessmentGeographical Information SystemsPesticides

Identifiers

PMID32166211
PMCPMC7028467
OpenAlexW2978170145

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.