ArticleBrain circulation
Demographic age-related variation in Circle of Willis completeness assessed by digital subtraction angiography.
Article in Brain circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Posterior communicating artery variation is linked to compromised cerebral hemodynamics in middle-aged and older adults.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Article
- Impact of Circle of Willis Anatomical Variations on Outcomes in Aneurysmal Subarachnoid Hemorrhage.Neurocritical care · 2026Article
- A systematic evaluation of the impact of contralateral stenosis on ipsilateral internal carotid artery hemodynamics using computational fluid dynamics.Quantitative imaging in medicine and surgery · 2025Article
- Anatomical study of variations in the configurations of the circle of Willis in relation to age, sex, and diameters of the components.Anatomy & cell biology · 2024Article
- Estimating Flow Direction of Circle of Willis Using Dynamic Arterial Spin-Labeling MR Angiography.AJNR. American journal of neuroradiology · 2024Article
- Anatomical variations in the circle of Willis on magnetic resonance angiography in a south Trinidad population.BJR open · 2024Article
- Age-related changes in the completeness of the circle of Willis in children.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022Article
- Prevalence and Risk Factors Comparison of Anterior and Posterior Intracranial Arterial Stenosis.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- MR Imaging Differences in the Circle of Willis between Healthy Children and Adults.AJNR. American journal of neuroradiology · 2021Article
- Circle of Willis variants are not associated with thrombectomy outcomes.Stroke and vascular neurology · 2021Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIncomplete circle of Willis (CoW) configuration is an important risk factor for cerebrovascular pathology, namely aneurysm formation and ischemic stroke. This study was performed to characterize CoW variation using digital subtraction angiography and to identify demographic and physiologic features that may influence the risk of having an incomplete CoW configuration. MATERIALS AND
methodsA retrospective review of 274 patients who underwent cerebral angiography by a single surgeon for any indication was conducted. Each CoW branch was graded as normal, hypoplastic, or aplastic. Univariate and multivariate regression analyses were conducted to assess the impact of age, gender, race, and certain comorbidities on CoW configuration.
resultsA complete CoW was identified in 37.23% of patients. In univariate analysis, patients <40 years old were more likely to have a complete CoW (odds ratio [OR]: 4.973, 95% confidence interval [CI]: 2.610-9.476,
conclusionsCoW configuration shows considerable variation with age; however, further investigation is required to elucidate the full impact of other demographic and vascular risk factors on CoW anatomy.
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