Evidence map›Paper›PMID 32166195›Full record

ReviewBrain circulation

Multiphase adjuvant neuroprotection: A novel paradigm for improving acute ischemic stroke outcomes.

Wenbo Zhao, Chuanjie Wu, David Dornbos, Sijie Li, Haiqing Song, Yuping Wang, Yuchuan Ding, Xunming Ji

2 registry-linked trialsOpen access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Brain circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 41 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 3 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03045055 phase2unknown statusnot on this map

A Proof-of-Concept Study Assessing the Safety and Efficacy of Remote Ischemic Conditioning for Acute Ischemic Stroke Patients Undergoing Endovascular Treatment

TypeinterventionalSponsorCapital Medical UniversityRan2020 to 2023Enrolled180ConditionsAcute StrokeArmsRemote ischemic conditioning., Endovascular treatment., Sham remote ischemic conditioning
NCT06559241 phase3recruitingnot on this map

Safety and Efficacy of Remote Ischemic Conditioning for Acute Ischemic Stroke Treated With Mechanical Thrombectomy (RECAST-MT): A Multicenter, Randomized, Controlled, Open-label, Blinded Endpoint Trial

TypeinterventionalSponsorCapital Medical UniversityRan2024 to 2027Enrolled2,105ConditionsAcute Ischemic Stroke, Anterior Circulation Brain InfarctionArms14-day remote ischemic conditioning, 30-day remote ischemic conditioning, Endovascular thrombectomy, Best medical management
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 3 syntheses or guidelines pooled it, 55 citations in OpenAlex.

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  20. Association between the time of day at stroke onset and functional outcome of acute ischemic stroke patients treated with endovascular therapy.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Wenbo ZhaoDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Chuanjie WuDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
David DornbosDepartment of Neurological Surgery, Semmes-Murphey Clinic and University of Tennessee Health Science Center, Memphis, TN, USA.
Sijie LiBeijing Key Laboratory of Hypoxia Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
Haiqing SongDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Yuping WangDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Yuchuan DingChina-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China.
Xunming JiBeijing Key Laboratory of Hypoxia Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
Capital Medical University · CNUniversity of Tennessee Health Science Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While several large pivotal clinical trials recently revealed a substantial benefit of endovascular thrombectomy for acute ischemic stroke (AIS) caused by large-vessel occlusion, many patients still experience mediocre prognosis. Enlargement of the ischemic core, failed revascularization, incomplete reperfusion, distal embolization, and secondary reperfusion injury substantially impact the salvaging of brain tissue and the functional outcomes of AIS. Here, we propose novel concept of "Multiphase Adjuvant Neuroprotection" as a new paradigm that may help guide our search for adjunctive treatments to be used together with thrombectomy. The premise of multiphase adjuvant neuroprotection is based on the diverse and potentially nonoverlapping pathophysiologic mechanisms that are triggered before, during, and after thrombectomy therapies. Before thrombectomy, strategies should focus on preventing the growth of the ischemic core; during thrombectomy, improving recanalization while reducing distal embolization and maximizing reperfusion are of significant importance; after reperfusion, strategies should focus on seeking targets to reduce secondary reperfusion injury. The concept of multiphase adjuvant neuroprotection, wherein different strategies are employed throughout the various phases of clinical care, might provide a paradigm to minimize the final infarct size and improve functional outcome in AIS patients treated with thrombectomy. With the success of thrombectomy in selected AIS patients, there is now an opportunity to revisit stroke neuroprotection. Notably, if the underlying mechanisms of these neuroprotective strategies are identified, their role in the distinct phases will provide further avenues to improve patient outcomes of AIS.

Indexed as

Acute ischemic strokeendovascular thrombectomyneuroprotectionpenumbrareperfusion injury

Identifiers

PMID32166195
PMCPMC7045534
OpenAlexW3008891422

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.