ArticleBrain and neuroscience advances
Combined allelic dosage of
Article in Brain and neuroscience advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Delineation of a Novel Mirror Syndrome: NFIC Variants Cause Syndromic Intellectual Disability With Macrocephaly.Clinical genetics · 2026Article
- Phosphorylation-dependent control of transcription factor activity regulates temporal patterning of cortical cell fate specification.Nature communications · 2026Article
- Transcriptional repression by TGIF2 coordinates neurogenic priming and neural stem cell maintenance.Science advances · 2026Article
- Structural basis for genome-wide site-specific DNA recognition by Nuclear Factor IA.Nature communications · 2025Article
- Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice.Nature neuroscience · 2025Article
- NFIA regulates articular chondrocyte fatty acid metabolism and joint homeostasis.Science translational medicine · 2025Article
- Cross-modal contrastive learning decodes developmental regulatory features through chromatin potential analysis.GigaScience · 2025Article
- Roles of the NFI/CTF gene family in transcription and development: update 2025.Academia biology · 2025Article
- PIN1 is a novel interaction partner and a negative upstream regulator of the transcription factor NFIB.FEBS letters · 2024Article
- Article
- Small Cell Lung Cancer Neuronal Features and Their Implications for Tumor Progression, Metastasis, and Therapy.Molecular cancer research : MCR · 2024Review
- Small Cell Lung Cancer Plasticity Enables NFIB-Independent Metastasis.Cancer research · 2024Article
- Deciphering the distinct transcriptomic and gene regulatory map in adult macaque basal ganglia cells.GigaScience · 2022Article
- Spatially resolved gene regulatory and disease-related vulnerability map of the adult Macaque cortex.Nature communications · 2022Article
- Dentate gyrus morphogenesis is regulated by β-catenin function in hem-derived fimbrial glia.Development (Cambridge, England) · 2022Article
- Capicua regulates the development of adult-born neurons in the hippocampus.Scientific reports · 2021Article
- DRAXIN regulates interhemispheric fissure remodelling to influence the extent of corpus callosum formation.eLife · 2021Article
- Common Regulatory Targets of NFIA, NFIX and NFIB during Postnatal Cerebellar Development.Cerebellum (London, England) · 2020Article
- Transcription factors NFIA and NFIB induce cellular differentiation in high-grade astrocytoma.Journal of neuro-oncology · 2020Article
- NFIB Haploinsufficiency Is Associated with Intellectual Disability and Macrocephaly.American journal of human genetics · 2018Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNuclear factor I family members nuclear factor I A and nuclear factor I B play important roles during cerebral cortical development. Nuclear factor I A and nuclear factor I B regulate similar biological processes, as their expression patterns, regulation of target genes and individual knockout phenotypes overlap. We hypothesised that the combined allelic loss of
methodsWe combined immunofluorescence, co-immunoprecipitation, gene expression analysis and immunohistochemistry on knockout mouse models to investigate whether nuclear factor I A and nuclear factor I B function similarly and whether increasing allelic loss of
resultsWe determined that the biological functions of nuclear factor I A and nuclear factor I B overlap during early cortical development. These proteins are co-expressed and can form heterodimers
conclusionIn the developing cerebral cortex, nuclear factor I A and nuclear factor I B share similar biological functions and function additively, as the combined allelic loss of these genes directly correlates with the severity of the developmental brain phenotype.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.