Evidence map›Paper›PMID 32165937›Full record

ArticleOpen access Macedonian journal of medical sciences2019

MicroRNAs as Potential Biomarkers for Childhood Epilepsy.

Hala G Elnady, Naglaa Abdelmoneam, Eman Eissa, Enas R Abdel Hamid, Dina Abu Zeid, Assem M Abo-Shanab, Hanan Atta, Naglaa M Kholoussi

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Article in Open access Macedonian journal of medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Evaluation of MicroRNAs in Pediatric Epilepsy.Turkish archives of pediatrics · 2023
    Article
  6. Review
  7. Article
  8. Review
  9. Posttranscriptional modulation of KCNQ2 gene expression by the miR-106b microRNA family.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  10. Review
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hala G ElnadyChild Health Department, Medical Research Division, National Research Centre, Giza, Egypt.
Naglaa AbdelmoneamPediatrics Department, Faculty of Medicine for Girls, Al Azhar University, Cairo, Egypt.
Eman EissaImmunogenetics Department, Human Genetics & Genome Research Division, National Research Centre, Giza, Egypt.
Enas R Abdel HamidChild Health Department, Medical Research Division, National Research Centre, Giza, Egypt.
Dina Abu ZeidChild Health Department, Medical Research Division, National Research Centre, Giza, Egypt.
Assem M Abo-ShanabImmunogenetics Department, Human Genetics & Genome Research Division, National Research Centre, Giza, Egypt.
Hanan AttaChild Health Department, Medical Research Division, National Research Centre, Giza, Egypt.
Naglaa M KholoussiImmunogenetics Department, Human Genetics & Genome Research Division, National Research Centre, Giza, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEpilepsy is the most frequent chronic neurologic condition in childhood. Its clinical diagnosis is based on electroencephalograms (EEG) and neuroimaging techniques. MicroRNAs (miRNAs) modulate gene expression of several genes and are aberrantly expressed in several diseases.

aimEvaluation of using circulating miR-106b and miR-146a as diagnostic and prognostic biomarkers in children patients with epilepsy.

methodsThirty epileptic children and twenty controls were enrolled in our study. They were assessed for the expression pattern of miR-106b and miR-146a in plasma using quantitative real-time PCR and determination of plasma Immunoglobulin levels.

resultsMiR-146a and miR-106b expression patterns were significantly up-regulated in children patients than that in normal controls. Plasma Immunoglobulins were differentially expressed in epileptic patients in comparison with healthy controls. No correlations were found between expression levels of miRNAs (miR-146a and miR-106b) and clinical data or immunoglobulin levels in children patients with epilepsy.

conclusionOur findings suggest that up-regulated plasma miR-106b and miR-146a could be used as biomarkers for epilepsy evaluation.

Indexed as

BiomarkerChildrenEpilepsymiR-106bmiR-146a

Identifiers

PMID32165937
PMCPMC7061375

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.