ArticleScientific reports2020
Sex differences in proximal femur shape: findings from a population-based study in adolescents.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Sex-Specific Adolescent Development of the Trochlea and Distal Femoral Physis: A 3D Shape Modeling Study.Orthopaedic journal of sports medicine · 2026Article
- DXA-derived hip shape is associated with hip fracture: a longitudinal study of 38 123 UK Biobank participants.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026Article
- Simulated microgravity models sex differences in knee osteoarthritis through a CD36-regulated mechano-metabolic circuit.Cell communication and signaling : CCS · 2026Article
- Comparison between UK Biobank and Shanghai Changfeng suggests distinct hip morphology may contribute to ethnic differences in the prevalence of hip osteoarthritis.Osteoarthritis and cartilage · 2025Article
- Parametric bionic hand-inspired optimization of femoral condylar prosthesis attachment surfaces.Frontiers in bioengineering and biotechnology · 2025Article
- Hip geometric parameters are associated with radiographic and clinical hip osteoarthritis: Findings from a cross-sectional study in UK Biobank.Osteoarthritis and cartilage · 2023Article
- The association between statistical shape modeling-defined hip morphology and features of early hip osteoarthritis in young adult football players: Data from the femoroacetabular impingement and hip osteoarthritis cohort (FORCe) study.Osteoarthritis and cartilage open · 2022Article
- Machine Learning-Derived Acetabular Dysplasia and Cam Morphology Are Features of Severe Hip Osteoarthritis: Findings From UK Biobank.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- Convenient design method for customized implants based on bionic vein structure features.Frontiers in bioengineering and biotechnology · 2022Article
- Engineered Human Meniscus in Modeling Sex Differences of Knee OsteoarthritisFrontiers in bioengineering and biotechnology · 2022Article
- Cam morphology but neither acetabular dysplasia nor pincer morphology is associated with osteophytosis throughout the hip: findings from a cross-sectional study in UK Biobank.Osteoarthritis and cartilage · 2021Article
- Bone morphological feature extraction for customized bone plate design.Scientific reports · 2021Article
- Male Sex Is Associated with Higher Mortality and Increased Risk for Complications after Surgical Treatment of Proximal Humeral Fractures.Journal of clinical medicine · 2021Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Hip shape is an important determinant of hip osteoarthritis (OA), which occurs more commonly in women. However, it remains unclear to what extent differences in OA prevalence are attributed to sex differences in hip shape. Here, we explore sex differences in proximal femur shape in a cohort of adolescents. Hip morphology was quantified using hip DXA scans from the Avon Longitudinal Study of Parents and Children. Independent modes of variation (hip shape mode (HSM) scores) were generated for each image using an adult reference statistical shape model (N = 19,379). Linear regression was used to examine sex differences for the top ten HSMs, adjusting for age, height, lean and fat mass. Complete outcome and covariate data were available for 4,428 and 4,369 participants at ages 14 and 18 years, respectively. Several HSMs showed sex differences at both time points. The combined effect of sex on hip shape at age 14 reflected flatter femoral head and smaller lesser trochanter in females compared with males and, following adjustment for age and body size, these differences became more pronounced. At age 18, smaller lesser trochanter and femoral neck width (FNW) in females still remained although differences in femoral head, femoral shaft and FNW were largely attenuated following adjustment. Sexual dimorphism in proximal femur shape can be discerned in adolescence and early adulthood. Observed differences in proximal femur shape, particularly at age 14 were largely independent of body size, however to what extent differences in hip shape in early life play a role in predisposing to hip OA in later life remains to be determined.
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