ArticleScientific reports2020
Electrophysiologically and behaviourally active semiochemicals identified from bed bug refuge substrate.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Bed bug preferences for host odor or aggregation odor are differentially modulated by physiological state in various odorscapes.Pest management science · 2026Article
- The effects of human volatiles produced by skin microbiota on Forcipomyia (Lasiohelea) taiwana host preference.Pest management science · 2025Article
- Functional Characterization of a Female-Biased Chemoreceptor of the Codling Moth (Cydia pomonella) Responding to Aldehydes and Other Volatile Compounds.Journal of chemical ecology · 2025Article
- Varroa Volatiles Offer Chemical Cues to Honey Bees for Initial Parasitic Recognition.Biomolecules · 2025Article
- Volatile Organic Compounds: A Promising Tool for Bed Bug Detection.International journal of environmental research and public health · 2023Review
- High-throughput behavioral phenotyping of tiny arthropods: Chemosensory traits in a mesostigmatic hematophagous mite.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2023Article
- Aldehyde-specific responses of olfactory sensory neurons in the praying mantis.Scientific reports · 2021Article
- The Olfactory Chemosensation of Hematophagous Hemipteran Insects.Frontiers in physiology · 2021Review
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
Abstract
Bed bugs are pests of public health importance due to their relentless biting habits that can lead to allergies, secondary infections and mental health issues. When not feeding on human blood bed bugs aggregate in refuges close to human hosts. This aggregation behaviour could be exploited to lure bed bugs into traps for surveillance, treatment efficacy monitoring and mass trapping efforts, if the responsible cues are identified. The aim of this study was to identify and quantify the bed bug aggregation pheromone. Volatile chemicals were collected from bed bug-exposed papers, which are known to induce aggregation behaviour, by air entrainment. This extract was tested for behavioural and electrophysiological activity using a still-air olfactometer and electroantennography, respectively. Coupled gas chromatography-electroantennography (GC-EAG) was used to screen the extract and the GC-EAG-active chemicals, benzaldehyde, hexanal, (E)-2-octenal, octanal, nonanal, decanal, heptanal, (R,S)-1-octen-3-ol, 3-carene, β-phellandrene, (3E,5E)-octadien-2-one, (E)-2-nonenal, 2-decanone, dodecane, nonanoic acid, 2-(2-butoxyethoxy)ethyl acetate, (E)-2-undecanal and (S)-germacrene D, were identified by GC-mass spectrometry and quantified by GC. Synthetic blends, comprising 6, 16, and 18 compounds, at natural ratios, were then tested in the still-air olfactometer to determine behavioural activity. These aggregation chemicals can be manufactured into a lure that could be used to improve bed bug management.
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Registered trials
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