ArticleScientific reports2020
Duan-Nai-An, A Yeast Probiotic, Improves Intestinal Mucosa Integrity and Immune Function in Weaned Piglets.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Engineered Phytoene-Producing Saccharomyces cerevisiae Alleviates Cyclophosphamide-Induced Intestinal Barrier Dysfunction and Gut Dysbiosis.Probiotics and antimicrobial proteins · 2026Article
- Impact ofMicroorganisms · 2024Article
- Role of immunomodulatory probiotics in alleviating bacterial diarrhea in piglets: a systematic review.Journal of animal science and biotechnology · 2024Review
- A new approach: preventive protocols with yeast products and essential oils can reduce the in-feed use of antibiotics in growing-finishing pigs.Translational animal science · 2024Article
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- Looking for Possible Benefits of Combining Short-Chain Fructo-Oligosaccharides (scFOS) withAnimals : an open access journal from MDPI · 2023Article
- Evaluation on the Growth Performance, Nutrient Digestibility, Faecal Microbiota, Noxious Gas Emission, and Faecal Score on Weaning Pigs Supplement with and without Probiotics Complex Supplementation in Different Level of Zinc Oxide.Animals : an open access journal from MDPI · 2023Article
- Review on Preventive Measures to Reduce Post-Weaning Diarrhoea in Piglets.Animals : an open access journal from MDPI · 2022Review
- Intestinal microbiota and its interaction to intestinal health in nursery pigs.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Review
- The Role of Probiotics in Alleviating Postweaning Diarrhea in Piglets From the Perspective of Intestinal Barriers.Frontiers in cellular and infection microbiology · 2022Review
- Evaluation of Dietary Probiotic (Animals : an open access journal from MDPI · 2021Article
- Effects of Dietary Yucca Schidigera Extract and OralFrontiers in nutrition · 2021Article
- Recent advances in the application of probiotic yeasts, particularly Saccharomyces, as an adjuvant therapy in the management of cancer with focus on colorectal cancer.Molecular biology reports · 2021Review
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Post-weaning diarrhea commonly occurs in piglets and results in significant economic loss to swine producers. Non-antibiotic measures for managing post-weaning diarrhea are critically needed. Duan-Nai-An, a probiotic produced from the yeast fermentation of egg whites, was previously shown to optimize intestinal flora and reduce the incidence of clinical diarrhea in weaning piglets. To study the effects of Duan-Nai-An on mucosal integrity and immunity in pig intestine, we examined the microstructure and ultrastructure of the intestines of weaned pigs with or without Duan-Nai-An as a feed supplement. The piglets of the Duan-Nai-An-fed group developed intestines with intact columnar epithelia covered by tightly packed microvilli on the apical surface. However, piglets of the control group (no supplement) showed villous atrophy and thinning, microvillus slough, and in the severe cases, damage of intestinal epithelia and exposure of the underlying lamina propria. Moreover, piglets of the Duan-Nai-An-fed group showed apparent plasmocyte hyperplasia, increased lymphoid nodule numbers, well-developed Peyer's Patchs, and apparent germinal centers. The lymphoid tissues of the control group were far less developed, showing lymph node atrophy, lymphocyte reduction, degeneration, and necrosis. These results indicate that Duan-Nai-An improves the development of the intestinal structures and lymphoid tissues and promotes intestinal health in weaned piglets.
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