Evidence map›Paper›PMID 32165573›Full record

ArticleScience (New York, N.Y.)2020

Treating sickle cell anemia.

John F Tisdale, Swee Lay Thein, William A Eaton

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Does Sickle Cell Anaemia Have a Relationship With Avascular Pulp Necrosis? A Systematic Review.Australian endodontic journal : the journal of the Australian Society of Endodontology Inc · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Review
  7. Observational
  8. Article
  9. Article
  10. Article
  11. A differentiated β-globin gene replacement strategy uses heterologous introns to restore physiological expression.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
    Article
  12. Article
  13. Clinical data comparison for FDA-approved gene therapies in sickle cell disease.Experimental biology and medicine (Maywood, N.J.) · 2025
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

John F TisdaleCellular and Molecular Therapeutics Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. johntis@nhlbi.nih.gov eaton@nih.gov sweelay.thein@nih.gov.
Swee Lay TheinSickle Cell Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. johntis@nhlbi.nih.gov eaton@nih.gov sweelay.thein@nih.gov.
William A EatonLaboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. johntis@nhlbi.nih.gov eaton@nih.gov sweelay.thein@nih.gov.

Funding

Sickle cell disease molecular pathogenesis and drug therapyZIADK029053 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI EATON, WILLIAM · 2009 to 2025
$24.8M
Isolation, characterization, and transplantation of candidate stem cellsZIAHL006009 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI TISDALE, JOHN · 2009 to 2025
$13.5M
Screening for a Drug for Sickle Cell DiseaseZ01DK029053 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI EATON, WILLIAM · 2007 to 2008
$669k
Intramural NIH HHS Z01 DK029053
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anemia, Sickle CellAntisickling AgentsGenetic TherapyHumansHydroxyureaStem Cell TransplantationAntisickling AgentsHydroxyurea

Identifiers

PMID32165573
PMCPMC7299198

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.