Evidence map›Paper›PMID 32165547›Full record

ArticlePostgraduate medical journal2021

Stroke and osteoporosis: a Taiwan cohort study.

Li Zhang, Zi-Hao Zhang, Qing-Rui Wang, Ying-Ju Su, Ying-Yi Lu, Cong-Liang Zhang, Hung-Pei Tsai, Chieh-Hsin Wu

Open access · hybridAbstract read
In one paragraph

Article in Postgraduate medical journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Bipolar disorder and the risk for stroke incidence and mortality: a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Pooled it
  3. Health education using customized aids for patients with osteoporotic vertebral fractures- a non-randomized controlled study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025
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  7. Causal associations of osteoporosis with stroke: a bidirectional Mendelian randomization study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Li ZhangDepartment of Neurosurgery, The Affiliated Zhangjiagang Hospital of Soochow University, Zhangjiagang, Jiangsu, P.R. China.
Zi-Hao ZhangDepartment of Neurosurgery, The No.7 People's Hospital of Hebei Province, Dingzhou, Hebei, P.R. China.
Qing-Rui WangDepartment of Neurosurgery, Qinghe County Central Hospital of Hebei Province, Qinghe, Hebei, P.R. China.
Ying-Ju SuDepartment of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Ying-Yi LuDepartment of Dermatology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Cong-Liang ZhangDepartment of Cardiology, Hebei Quyang Renji Hospital, Quyang, Hebei, P.R. China.
Hung-Pei TsaiDivision of Neurosurgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.ORCID http://orcid.org/0000-0001-9170-6268
Chieh-Hsin WuDivision of Neurosurgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan wujoeys@gmail.com.ORCID http://orcid.org/0000-0001-5116-8004
Kaohsiung Medical University · TWHospital of Hebei Province · CNRenji Hospital · CNSoochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOsteoporosis and stroke are major health problems that have potentially overlapping pathophysiological mechanisms. The aim of this study was to estimate osteoporosis risk in Taiwan patientswho had a stroke.

methodThis study retrieved data contained in the Taiwan National Health Insurance Research Database for a population-based sample of consecutive patients either hospitalised for stroke or treated for stroke on an outpatient basis. A total of 7550 newly diagnosed patientswho had a stroke were enrolled during 1996-2010. Osteoporosis risk in these patients was then compared with a matched group of patients who had not had a stroke randomly selected from the database at a ratio of 1:4 (n=30 200). The relationship between stroke history and osteoporosis risk was estimated with Cox proportional hazard regression models.

resultsDuring the follow-up period, osteoporosis developed in 1537 patients who had a stroke and in 5830 patients who had not had a stroke. The incidence of osteoporosis for cohorts with and without stroke was 32.97 and 14.28 per 1000 person-years, respectively. After controlling for covariates, the overall risk of osteoporosis was 1.82-fold higher in the stroke group than in the non-stroke group. The relative osteoporosis risk contributed by stroke had apparently greater impact among male gender and younger age groups.

conclusionHistory of stroke is a risk factor for osteoporosis in Taiwan. Much attention to stroke-targeted treatment modalities might minimise adverse outcomes of osteoporosis.

Indexed as

Risk AssessmentAgedAge FactorsCase-Control StudiesCohort StudiesFemaleHumansIncidenceMaleMiddle AgedOsteoporosisProportional Hazards ModelsSex FactorsStrokeTaiwancohort studyosteoporosisstroke

Identifiers

PMID32165547
PMCPMC8005805
OpenAlexW3011810078

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.