Evidence map›Paper›PMID 32165498›Full record

ArticleThe Journal of biological chemistry2020

Cell-specific expression of the transcriptional regulator RHAMM provides a timing mechanism that controls appropriate wound re-epithelialization.

Cornelia Tolg, Muhan Liu, Katelyn Cousteils, Patrick Telmer, Khandakar Alam, Jenny Ma, Leslie Mendina, James B McCarthy, Vincent L Morris, Eva A Turley

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

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  12. "Annals of pancreatic cancer · 2022
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  17. RHAMM Is a Multifunctional Protein That Regulates Cancer Progression.International journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Cornelia TolgLondon Regional Cancer Program, London Health Sciences Centre, Victoria Hospital, London, Ontario N6A 4L6, Canada.
Muhan LiuLondon Regional Cancer Program, London Health Sciences Centre, Victoria Hospital, London, Ontario N6A 4L6, Canada.
Katelyn CousteilsDepartment of Biochemistry, Western University, London, Ontario N6A 5C1, Canada.
Patrick TelmerLondon Regional Cancer Program, London Health Sciences Centre, Victoria Hospital, London, Ontario N6A 4L6, Canada.
Khandakar AlamLondon Regional Cancer Program, London Health Sciences Centre, Victoria Hospital, London, Ontario N6A 4L6, Canada.
Jenny MaLondon Regional Cancer Program, London Health Sciences Centre, Victoria Hospital, London, Ontario N6A 4L6, Canada.
Leslie MendinaLondon Regional Cancer Program, London Health Sciences Centre, Victoria Hospital, London, Ontario N6A 4L6, Canada.
James B McCarthyDepartment of Laboratory Medicine and Pathology, Masonic Cancer Center, Minneapolis, Minnesota 55455.
Vincent L MorrisDepartment of Microbiology and Immunology, Western University, London, Ontario N6A 3K7, Canada.
Eva A TurleyLondon Regional Cancer Program, London Health Sciences Centre, Victoria Hospital, London, Ontario N6A 4L6, Canada; Departments of Oncology, Biochemistry, and Surgery, Schulich School of Medicine, Western University, London, Ontario N6A 5C1, Canada. Electronic address: Eva.Turley@lhsc.on.ca.
London Health Sciences Centre · CAWestern University · CAMasonic Cancer Center

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prevention of aberrant cutaneous wound repair and appropriate regeneration of an intact and functional integument require the coordinated timing of fibroblast and keratinocyte migration. Here, we identified a mechanism whereby opposing cell-specific motogenic functions of a multifunctional intracellular and extracellular protein, the receptor for hyaluronan-mediated motility (RHAMM), coordinates fibroblast and keratinocyte migration speed and ensures appropriate timing of excisional wound closure. We found that, unlike in WT mice, in

Indexed as

Re-EpithelializationAnimalsCell LineCell MovementCells, CulturedExtracellular Matrix ProteinsFibroblastsHyaluronan ReceptorsKeratinocytesMAP Kinase Signaling SystemMatrix Metalloproteinase 9MiceMice, Inbred C57BLMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Extracellular Matrix Proteinshyaluronan-mediated motility receptorHyaluronan ReceptorsMatrix Metalloproteinase 9Mitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Mmp9 protein, mousecell migrationcell signalingextracellular matrixhyaluronankeratinocytekeratinocytesRHAMMwound healingwound repair

Identifiers

PMID32165498
PMCPMC7170511
OpenAlexW3012107750

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.