Evidence map›Paper›PMID 32165376›Full record

ArticleJournal of neurology, neurosurgery, and psychiatry2020

Ten-year risks of recurrent stroke, disability, dementia and cost in relation to site of primary intracerebral haemorrhage: population-based study.

Linxin Li, Ramon Luengo-Fernandez, Susanna M Zuurbier, Nicola C Beddows, Philippa Lavallee, Louise E Silver, Wilhelm Kuker, Peter Malcolm Rothwell

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, neurosurgery, and psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Linxin LiCentre for Prevention of Stroke and Dementia, University of Oxford, Oxford, Oxfordshire, UK.ORCID 0000-0002-3636-8355
Ramon Luengo-FernandezCentre for Prevention of Stroke and Dementia, University of Oxford, Oxford, Oxfordshire, UK.
Susanna M ZuurbierCentre for Prevention of Stroke and Dementia, University of Oxford, Oxford, Oxfordshire, UK.
Nicola C BeddowsCentre for Prevention of Stroke and Dementia, University of Oxford, Oxford, Oxfordshire, UK.
Philippa LavalleeCentre for Prevention of Stroke and Dementia, University of Oxford, Oxford, Oxfordshire, UK.
Louise E SilverCentre for Prevention of Stroke and Dementia, University of Oxford, Oxford, Oxfordshire, UK.
Wilhelm KukerCentre for Prevention of Stroke and Dementia, University of Oxford, Oxford, Oxfordshire, UK.
Peter Malcolm RothwellCentre for Prevention of Stroke and Dementia, University of Oxford, Oxford, Oxfordshire, UK peter.rothwell@ndcn.ox.ac.uk.
University of Oxford · GB

Funding

British Heart FoundationWellcome Trust
6 · The paper itself

Abstract

backgroundPatients with primary intracerebral haemorrhage (ICH) are at increased long-term risks of recurrent stroke and other comorbidities. However, available estimates come predominantly from hospital-based studies with relatively short follow-up. Moreover, there are also uncertainties about the influence of ICH location on risks of recurrent stroke, disability, dementia and quality of life.

methodsIn a population-based study (Oxford Vascular Study/2002-2018) of patients with a first ICH with follow-up to 10 years, we determined the long-term risks of recurrent stroke, disability, quality of life, dementia and hospital care costs stratified by haematoma location.

resultsOf 255 cases with primary ICH (mean/SD age 75.5/13.1), 109 (42.7%) had lobar ICH, 144 (56.5%) non-lobar ICH and 2 (0.8%) had uncertain location. Annual rates of recurrent ICH were higher after lobar versus non-lobar ICH (lobar=4.0%, 2.7-7.2 vs 1.1%, 0.3-2.8; p=0.02). Moreover, cumulative rate of dementia was also higher for lobar versus non-lobar ICH (n/% lobar=20/36.4% vs 16/20.8%, p=0.047), and there was a higher proportion of disability at 5 years in survivors (15/60.0% vs 9/31.0%, p=0.03). The 10-year quality-adjusted life years (QALYs) were also lower after lobar versus non-lobar ICH (2.9 vs 3.8 for non-lobar, p=0.04). Overall, the mean 10-year censor-adjusted costs were £19 292, with over 80% of costs due to inpatient hospital admission costs, which did not vary by haematoma location (p=0.90).

conclusionCompared with non-lobar ICH, the substantially higher 10-year risks of recurrent stroke, dementia and lower QALYs after lobar ICH highlight the need for more effective prevention for this patient group.

Indexed as

Health Care CostsQuality of LifeAgedAged, 80 and overBrain IschemiaCerebral HemorrhageDementiaFemaleHumansIncidenceMaleMiddle AgedRecurrenceRiskStroke

Identifiers

PMID32165376
PMCPMC7279204
OpenAlexW3011837564

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.