ArticleContact lens & anterior eye : the journal of the British Contact Lens Association2020
Scleral lens wear: Measuring inflammation in the fluid reservoir.
Article in Contact lens & anterior eye : the journal of the British Contact Lens Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Scleral Lens Fenestrations and Fluid Reservoir Debris.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Presence of Eyelid Disease in Habitual Scleral Lens Wearers.Journal of clinical medicine · 2026Article
- Slit Lamp Findings in Scleral Lens Wearers With and Without Subjective Fogging.Eye & contact lens · 2025Observational
- Potential pro-inflammatory impact of scleral lens midday fogging on human corneal epithelial cells: An in vitro study.Contact lens & anterior eye : the journal of the British Contact Lens Association · 2024Article
- Scleral Lenses for Managing Dry Eye Disease in the Absence of Corneal Irregularities: What Is the Current Evidence?Journal of clinical medicine · 2024Review
- Nonpolar Lipids Contribute to Midday Fogging During Scleral Lens Wear.Investigative ophthalmology & visual science · 2023Article
- The impact of hybrid contact lenses on keratoconus progression after accelerated transepithelial corneal cross-linking.International ophthalmology · 2021Article
- Midday Fogging of Scleral Contact Lenses: Current Perspectives.Clinical optometry · 2021Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
purposeTo measure inflammatory mediators in the scleral lens fluid reservoir (FR) in healthy eyes and to compare them to basal tear samples after 8-hs (8h) and 4-days (4d) of scleral lens (SL) wear.
methodsFifteen normal, habitual soft contact lens wearers were fitted with 14.8- or 15.4-mm SLs (Zenlens, Alden Optical, USA). Basal ocular surface tears and FR samples were collected after 8h and 4d of daily SL wear. Levels of interleukin (IL) -4 and -8, matrix metalloproteinase (MMP)-7, -9, and -10, and tissue inhibitor of MMPs (TIMPs) 1-4 were measured in all samples using Luminex assays. Visual acuity, corneal and conjunctival staining, and comfort assessments were completed at the baseline, 8h and 4d time points.
resultsMMP-9 and MMP-10 were greater in FR than basal ocular surface tears. After 8h of SL wear, the median concentration of MMP-9 in the FR and basal tears were 62.7 and 15.2 ng/mL, respectively (p = 0.047). Likewise, MMP-10 was significantly greater in FR compared to basal tears, after 8h (25.8 ng/mL vs 2.8 ng/mL, p < 0.001) and 4d (2.1 ng/mL vs17.2 ng/mL, p = 0.047). IL-4 and IL-8 levels were greater in FR but not significantly at 8h (2.2 vs 3.1 ng/mL; and 0.1 vs 0.4 ng/mL, respectively) or 4d (0.9 vs 3.5 ng/mL; 0.0 vs 0.2 ng/mL). MMP-7 was not affected by SL wear after 8h (46.0 basal vs 54.4 ng/mL FR) or 4d (34.2 vs 87.5 ng/mL). Visual acuity, corneal and conjunctival staining did not change; comfort was reduced in SL compared to soft contact lens wear.
conclusionsThis is the first study to compare the FR with the basal ocular surface tears. MMP-9 and MMP-10 were elevated in the FR after several hours of SL wear, suggesting potential clinical implications of SL wear and deserves further investigation.
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