Evidence map›Paper›PMID 32164875›Full record

ArticleNeuron2020

Hierarchical Representations of Aggression in a Hypothalamic-Midbrain Circuit.

Annegret L Falkner, Dongyu Wei, Anjeli Song, Li W Watsek, Irene Chen, Patricia Chen, James E Feng, Dayu Lin

Open access · bronzeAbstract read
In one paragraph

Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
18.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 124 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Neural basis of social hierarchy across species.Nature reviews. Neuroscience · 2026
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Neural plasticity supporting parental behaviors.Current opinion in neurobiology · 2025
    Review
  11. Serotonin modulates nucleus accumbens circuits to suppress aggression.bioRxiv : the preprint server for biology · 2025
    Article
  12. Trigeminal Motor Nucleus Regulates Microstructure of Feeding Behavior without Affecting Total Food Intake.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  13. Familiarity Gates Socially Transmitted Aggression via the Medial Amygdala.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  14. Article
  15. Review
  16. Article
  17. CART Neurons in the Hypothalamic Ventral Premammillary Nucleus (PMv) in Rats Mediate Maternal, But Not Inter-male Aggression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  18. Article
  19. Article
  20. Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Annegret L FalknerPrinceton Neuroscience Institute, Princeton, NJ 08540, USA; Neuroscience Institute, New York University School of Medicine, New York, NY 10016, USA. Electronic address: afalkner@princeton.edu.
Dongyu WeiNeuroscience Institute, New York University School of Medicine, New York, NY 10016, USA.
Anjeli SongBoston University School of Medicine, Boston, MA 02118, USA.
Li W WatsekNeuroscience Institute, New York University School of Medicine, New York, NY 10016, USA.
Irene ChenNeuroscience Institute, New York University School of Medicine, New York, NY 10016, USA.
Patricia ChenPrinceton Neuroscience Institute, Princeton, NJ 08540, USA.
James E FengNeuroscience Institute, New York University School of Medicine, New York, NY 10016, USA.
Dayu LinNeuroscience Institute, New York University School of Medicine, New York, NY 10016, USA; Department of Psychiatry, New York University School of Medicine, New York, NY 10016, USA; Center for Neural Science, New York University, New York, NY 10003, USA.
New York University · USPrinceton University · USBoston University · US

Funding

U19 Supplement 2023-FroemkeU19NS107616 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RICHARD W TSIEN · 2018 to 2026
$36.4M
Research Supplement to Promote Diversity in Health-Related ResearchR01MH101377 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Dayu Lin · 2013 to 2026
$8.6M
Mapping experience-dependent change in a circuit for aggressionR01MH126035 · NIMH · PRINCETON UNIVERSITY · PI FALKNER, ANNEGRET LEA · 2021 to 2025
$2.6M
Dissecting the neural circuits of maternal behaviorsR01HD092596 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LIN, DAYU · 2018 to 2022
$2.4M
Inhibitory Control of Hypothalamic Circuit for AggressionR00MH109674 · NIMH · PRINCETON UNIVERSITY · PI FALKNER, ANNEGRET LEA · 2018 to 2020
$743k
Understand the neural mechanism underlying aggressive motivationR21MH105774 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LIN, DAYU · 2016 to 2017
$466k
Inhibitory control of a hypothalamic circuit for aggressionK99MH109674 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FALKNER, ANNEGRET LEA · 2016 to 2017
$198k
NICHD NIH HHS R01 HD092596NIMH NIH HHS K99 MH109674NIMH NIH HHS R00 MH109674NIMH NIH HHS R01 MH101377NIMH NIH HHS R01 MH126035NIMH NIH HHS R21 MH105774NINDS NIH HHS U19 NS107616
6 · The paper itself

Abstract

Although the ventromedial hypothalamus ventrolateral area (VMHvl) is now well established as a critical locus for the generation of conspecific aggression, its role is complex, with neurons responding during multiple phases of social interactions with both males and females. It has been previously unclear how the brain uses this complex multidimensional signal and coordinates a discrete action: the attack. Here, we find a hypothalamic-midbrain circuit that represents hierarchically organized social signals during aggression. Optogenetic-assisted circuit mapping reveals a preferential projection from VMHvl

Indexed as

AggressionAnimalsFemaleMaleMesencephalonMiceNeural PathwaysNeuronsVentromedial Hypothalamic Nucleusaggressioncircuithypothalamusjaw muscleperiaqueductal graysocial behavior

Identifiers

PMID32164875
PMCPMC7571490
OpenAlexW3011727833

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.