SynthesisBMC gastroenterology2020
Long-term outcomes and quality of life of patients with Hirschsprung disease: a systematic review and meta-analysis.
Synthesis in BMC gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Hirschsprung disease and associated urological morbidities: institutional experience and systemic review.World journal of urology · 2026Pooled it
- Outcomes of robotic-assisted soave pull-through procedure for Hirschsprung disease: a systematic review and meta-analysis.Journal of robotic surgery · 2026Pooled it
- Volume-outcome relationship in corrective surgery for Hirschsprung's disease: a systematic literature review of direct evidence and an overview of indirect evidence.Pediatric surgery international · 2025Pooled it
- A systematic review of school functioning in pediatric patients with Hirschsprung disease.Pediatric surgery international · 2025Pooled it
- Meta-analysis of Long-Term Relapse Rate of Type 2 Diabetes Following Initial Remission After Roux-en-Y Gastric Bypass.Obesity surgery · 2021Pooled it
- Bowel function at preschool and early childhood age in children with long-segment Hirschsprung disease.European journal of pediatrics · 2023Trial
- Laparoscopic Versus Robotic Yancey-Soave Primary Pull-Through in Rectosigmoid Hirschsprung Disease: A Systematic Review of the Literature.Children (Basel, Switzerland) · 2026Review
- The PODCAST-question: postoperative dilation versus calibration after surgical treatment of Hirschsprung's disease-what is necessary?Pediatric surgery international · 2026Article
- Beyond aganglionosis: BCL-2 and Laminin signatures Elucidate Hirschsprung disease and Hirschsprung-Associated Enterocolitis pathogenesis.Pediatric research · 2026Article
- Multidisciplinary management of postoperative continence issues in rectosigmoid Hirschsprung disease: a unicentric experience on 86 patients.Pediatric surgery international · 2026Article
- School toilet facilities perception of children with hirschsprung disease: a parents perspective.Pediatric surgery international · 2025Article
- Altered Development of Gut Microbiota and Gastrointestinal Inflammation in Children with Post-Operative Hirschsprung's Disease.International journal of molecular sciences · 2025Article
- Strong agreement between self-administered and interview-obtained bowel function score in patients with Hirschsprung disease and anorectal malformation.Pediatric surgery international · 2025Article
- Features of defecation dysfunction among patients with Hirschsprung disease in early childhood.BMC gastroenterology · 2025Observational
- Post pull- through bowel function outcome and contributing factors in children; a cross-sectional study from low resource setting.BMC surgery · 2025Article
- Surgical long-term outcomes of Hirschsprung Disease in the Democratic Republic of Congo: a case series of 31 patients in a resource-limited setting.BMC surgery · 2025Article
- Long-term outcomes of laparoscopic-assisted versus complete transanal endorectal pull-through technique for classic segment Hirschsprung's disease.Pediatric surgery international · 2024Article
- Prevalence and Factors associated with Bowel Dysfunctions after Pull-Through Surgery in Children Diagnosed with Hirschsprung Disease.Pediatric gastroenterology, hepatology & nutrition · 2024Article
- Bowel Function Score in Long-Term Follow-Up for Children with Hirschsprung Disease: OASIS-Holistic Care in Hirschsprung Disease Network Position Paper.Children (Basel, Switzerland) · 2024Article
- RET Signaling Persists in the Adult Intestine and Stimulates Motility by Limiting PYY Release From Enteroendocrine Cells.Gastroenterology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdvances in surgical techniques and perioperative care have improved the short- and mid-term postoperative outcomes of patients with Hirschsprung disease (HD). However, the long-term outcomes of these patients (older than 10 years) have not been fully investigated. The aim of this systematic review is to clarify the prevalence of long-term outcomes and the quality of life of these patients.
methodsPubMed, AMED, Cochrane Library, CINAHL and PsycINFO databases were searched from inception to October 2018, following the Meta-analysis of Observational Studies in Epidemiology (MOOSE) guideline. Original studies reporting the outcomes of patients older than ten years with HD were selected and reviewed. The overall prevalence of fecal incontinence, constipation, bowel function score, bladder dysfunction symptoms, and patients' quality of life were extracted from the included studies and pooled through the random-effects meta-analysis model. The heterogeneity and variation in the pooled estimations were evaluated by Cochrane's Q test and the I
resultsIn total, 3406 articles were identified from the literature search, among which twelve studies, including 625 patients, were included for analysis. The pooled prevalences of fecal incontinence, constipation, and bladder dysfunction symptoms and good to excellent bowel function scores were 0.20 (95% CI 0.13-0.28), 0.14 (95% CI 0.06-0.25), 0.07 (95% CI 0.04-0.12), and 0.95 (95% CI: 0.91-0.97), respectively; the pooled mean score of gastrointestinal-related quality of life was 118 (95% CI: 112.56-123.44).
conclusionsHD patients older than ten years old have an overall high prevalence of fecal incontinence and a low quality of life. Targeted and evidence-based follow-up procedures and transitional care are essential to meet these patients' long-term care needs. Prospective and multicenter research that focuses on the attributes and predictors of the long-term prognosis of patients with HD are necessary.
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