Evidence map›Paper›PMID 32164386›Full record

ArticleCells2020

Exosomes from Human Adipose Tissue-Derived Mesenchymal Stem Cells Promote Epidermal Barrier Repair by Inducing de Novo Synthesis of Ceramides in Atopic Dermatitis.

Kyong-Oh Shin, Dae Hyun Ha, Jin Ock Kim, Debra A Crumrine, Jason M Meyer, Joan S Wakefield, Yerin Lee, Bogyeong Kim, Sungeun Kim, Hyun-Keun Kim and 10 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07372001 (Effects on Facial Skin Aging After Topical Application of Exosomes With a Microneedling Device), which is not on this map. Cited by 116 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed, 1 pooled it
15.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07372001 phase4completednot on this mapstarted 2024, after this paper: background citation

Effects on Facial Skin Aging After Topical Application of Exosomes With a Microneedling Device

TypeinterventionalSponsorInstituto de Oftalmología Fundación Conde de ValencianaRan2024 to 2025Enrolled30ConditionsSkin AgingArmsTopical lyophilized exosomes application
3 · Its place in the literature

Who cites it

116 citing papers in PubMed, 1 synthesis or guideline pooled it, 194 citations in OpenAlex.

  1. Pooled it
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  5. Exosomes in precision dermatology: From biomarkers to targeted therapeutics in personalized care.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
    Review
  6. Characterization ofInternational journal of molecular sciences · 2026
    Article
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56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 2 countries.

Kyong-Oh ShinDepartment of Food Science and Nutrition, Convergence Program of Material Science for Medicine and Pharaceutics, Hallym University, Chuncheon 24252, Korea.
Dae Hyun HaExoCoBio Exosome Institute (EEI), ExoCoBio Inc., Seoul 08594, Korea.
Jin Ock KimExoCoBio Exosome Institute (EEI), ExoCoBio Inc., Seoul 08594, Korea.
Debra A CrumrineDepartment of Dermatology, University of California, NCIRE, and Veterans Affairs Medical Center, San Francisco, CA 94115, USA.
Jason M MeyerDepartment of Dermatology, University of California, NCIRE, and Veterans Affairs Medical Center, San Francisco, CA 94115, USA.
Joan S WakefieldDepartment of Dermatology, University of California, NCIRE, and Veterans Affairs Medical Center, San Francisco, CA 94115, USA.
Yerin LeeDepartment of Food Science and Nutrition, Convergence Program of Material Science for Medicine and Pharaceutics, Hallym University, Chuncheon 24252, Korea.
Bogyeong KimDepartment of Food Science and Nutrition, Convergence Program of Material Science for Medicine and Pharaceutics, Hallym University, Chuncheon 24252, Korea.
Sungeun KimDepartment of Food Science and Nutrition, Convergence Program of Material Science for Medicine and Pharaceutics, Hallym University, Chuncheon 24252, Korea.
Hyun-Keun KimExoCoBio Exosome Institute (EEI), ExoCoBio Inc., Seoul 08594, Korea.
Joon LeeSchool of Chemical and Biological Engineering, Seoul National University, Seoul 08826, Korea.
Hyuck Hoon KwonOaro Dermatology Clinic, Seoul 13620, Korea.
Gyeong-Hun ParkDepartment of Dermatology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong-si, Gyeonggi-do 18450, Korea.
Jun Ho LeeExoCoBio Exosome Institute (EEI), ExoCoBio Inc., Seoul 08594, Korea.
Jihye LimExoCoBio Exosome Institute (EEI), ExoCoBio Inc., Seoul 08594, Korea.
Sejeong ParkExoCoBio Exosome Institute (EEI), ExoCoBio Inc., Seoul 08594, Korea.
Peter M EliasDepartment of Dermatology, University of California, NCIRE, and Veterans Affairs Medical Center, San Francisco, CA 94115, USA.
Kyungho ParkDepartment of Food Science and Nutrition, Convergence Program of Material Science for Medicine and Pharaceutics, Hallym University, Chuncheon 24252, Korea.
Yong Weon YiExoCoBio Exosome Institute (EEI), ExoCoBio Inc., Seoul 08594, Korea.
Byong Seung ChoExoCoBio Exosome Institute (EEI), ExoCoBio Inc., Seoul 08594, Korea.
Hallym University · KRSan Francisco VA Medical Center · USSeoul National University · KRHallym University Dongtan Sacred Heart Hospital · KR

Funding

UCSF Dermatology Training GrantT32AR007175 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Wilson Liao, Michael David Rosenblum · 1986 to 2026
$6.1M
NIAMS NIH HHS T32 AR007175
6 · The paper itself

Abstract

Atopic dermatitis (AD) is a multifactorial, heterogeneous disease associated with epidermal barrier disruption and intense systemic inflammation. Previously, we showed that exosomes derived from human adipose tissue-derived mesenchymal stem cells (ASC-exosomes) attenuate AD-like symptoms by reducing multiple inflammatory cytokine levels. Here, we investigated ASC-exosomes' effects on skin barrier restoration by analyzing protein and lipid contents. We found that subcutaneous injection of ASC-exosomes in an oxazolone-induced dermatitis model remarkably reduced trans-epidermal water loss, while enhancing stratum corneum (SC) hydration and markedly decreasing the levels of inflammatory cytokines such as IL-4, IL-5, IL-13, TNF-α, IFN-γ, IL-17, and TSLP, all in a dose-dependent manner. Interestingly, ASC-exosomes induced the production of ceramides and dihydroceramides. Electron microscopic analysis revealed enhanced epidermal lamellar bodies and formation of lamellar layer at the interface of the SC and stratum granulosum with ASC-exosomes treatment. Deep RNA sequencing analysis of skin lesions demonstrated that ASC-exosomes restores the expression of genes involved in skin barrier, lipid metabolism, cell cycle, and inflammatory response in the diseased area. Collectively, our results suggest that ASC-exosomes effectively restore epidermal barrier functions in AD by facilitating the de novo synthesis of ceramides, resulting in a promising cell-free therapeutic option for treating AD.

Indexed as

Adipose TissueAnimalsCeramidesDermatitis, AtopicEpidermisExosomesFemaleHumansMesenchymal Stem CellsMiceCeramidesanti-inflammationASC-exosomesatopic dermatitisceramideslamella bodyrestorationskin barrier

Identifiers

PMID32164386
PMCPMC7140723
OpenAlexW3012118032

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.