ArticleJournal of chemical theory and computation2020
Could Microwave Irradiation Cause Misfolding of Peptides?
Article in Journal of chemical theory and computation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 17 citations in OpenAlex.
- Effect of Microwave on Protein Conformations and Enzymatic Reactions.Molecules (Basel, Switzerland) · 2026Review
- Formation of reactive species via high power microwave induced DNA damage and promoted intrinsic pathway-mediated apoptosis in lung cancer cells: AnFundamental research · 2024Article
- The Effect of Microwaves on Protein Structure: Molecular Dynamics Approach.Journal of chemical information and modeling · 2024Article
- Inhibition of ferroptosis alleviates high-power microwave-induced myocardial injury.Frontiers in cardiovascular medicine · 2023Article
- Molecular dynamics simulations explore effects of electric field orientations on spike proteins of SARS-CoV-2 virions.Scientific reports · 2022Article
- Pulsed 3.5 GHz high power microwaves irradiation on physiological solution and their biological evaluation on human cell lines.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microwaves have been experimentally shown to affect the folding dynamics of peptides and proteins. Using molecular dynamics, we performed all-atom simulations of a model β-peptide in aqueous solution where individual degrees of freedom of solvent molecules were decoupled to allow for investigation at non-equilibrium microwave-irradiated conditions. An elevated rotational temperature of the water medium was found to significantly affect the conformation of the peptide due to the weakened hydrogen-bonding interactions with the surrounding solvent molecules. Cluster analysis revealed that microwave irradiation can indeed act as a promoter in the formation of new misfolded peptide structures of the hairpin type, which are generally associated with the onset of several neurodegenerative disorders such as Alzheimer's, Parkinson's, Huntington's, and Creutzfeldt-Jakob diseases as well as certain cancer types such as amyloidosis.
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Registered trials
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