Evidence map›Paper›PMID 32163656›Full record

ArticleJournal of cellular and molecular medicine2020

Knockout of AKAP150 improves impaired BK channel-mediated vascular dysfunction through the Akt/GSK3β signalling pathway in diabetes mellitus.

Yan-Rong Zhu, Xiao-Xin Jiang, Peng Ye, Zhi-Mei Wang, Yaguo Zheng, Zhizhong Liu, Shao-Liang Chen, Dai-Min Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yan-Rong ZhuDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Xiao-Xin JiangDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Peng YeDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Zhi-Mei WangDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Yaguo ZhengDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Zhizhong LiuDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Shao-Liang ChenDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Dai-Min ZhangDepartment of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.ORCID 0000-0001-5251-3113
Nanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vascular dysfunction resulting from diabetes is an important factor in arteriosclerosis. Previous studies have shown that during hyperglycaemia and diabetes, AKAP150 promotes vascular tone enhancement by intensifying the remodelling of the BK channel. However, the interaction between AKAP150 and the BK channel remains open to discussion. In this study, we investigated the regulation of impaired BK channel-mediated vascular dysfunction in diabetes mellitus. Using AKAP150 null mice (AKAP150

Indexed as

A Kinase Anchor ProteinsAnimalsArteriosclerosisDiabetes ComplicationsDiabetes Mellitus, ExperimentalDisease Models, AnimalGlycogen Synthase Kinase 3 betaHumansHyperglycemiaLarge-Conductance Calcium-Activated Potassium Channel beta SubunitsLarge-Conductance Calcium-Activated Potassium ChannelsMiceMice, KnockoutRNA, Small InterferingAkap5 protein, mouseA Kinase Anchor ProteinsGlycogen Synthase Kinase 3 betaGsk3b protein, mouseKcnmb1 protein, mouseLarge-Conductance Calcium-Activated Potassium Channel beta SubunitsLarge-Conductance Calcium-Activated Potassium ChannelsRNA, Small InterferingA-kinase anchoring proteindiabetes mellitusthe large-conductance Ca2+-activated K+ channelvascular diseasesvascular smooth muscle cells

Identifiers

PMID32163656
PMCPMC7176888
OpenAlexW3010882103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.