Evidence map›Paper›PMID 32163053›Full record

ArticleChemical communications (Cambridge, England)2020

Visible photorelease of liquid biopsy markers following microfluidic affinity-enrichment.

Thilanga N Pahattuge, J Matt Jackson, Rane Digamber, Harshani Wijerathne, Virginia Brown, Malgorzata A Witek, Chamani Perera, Richard S Givens, Blake R Peterson, Steven A Soper

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. [Recent advances in responsive isolation, release and clinical application of circulating tumor cells].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Thilanga N PahattugeCenter of BioModular Multi-Scale Systems, Department of Chemistry, University of Kansas, 1567 Irving Hill Rd., Lawrence, KS 66045, USA. ssoper@ku.edu.
J Matt Jackson
Rane Digamber
Harshani Wijerathne
Virginia Brown
Malgorzata A Witek
Chamani Perera
Richard S Givens
Blake R Peterson
Steven A Soper

Funding

Transgenic & Gene-Targeting Shared ResourceP30CA168524 · NCI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI NICOLE L NOLLEN · 2012 to 2026
$40.1M
Understanding the mechanobiology of stem cells in a microengineered 3D cardiac tissue environment with cardiomyopathyP20GM103638 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI HOLMSTROM, ERIK D · 2012 to 2021
$22.1M
Using Integrated Omics to Identify Dysfunctional Genetic Mechanisms Influencing Schizophrenia and Sleep DisturbancesP20GM130423 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI ANDREW K. GODWIN · 2019 to 2026
$21.5M
Single-Molecule Processing: Detection and Identification of Single DNAs, RNAs, and Proteins using Immobilized Nanoscale Enzymatic Reactors (INERs) and Nanoscale ElectrophoresisP41EB020594 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Adam Roger Hall · 2015 to 2026
$15.2M
Synthetic Lethal Targeting of Growth Factor ReceptorsR01CA211720 · NCI · UNIVERSITY OF KANSAS LAWRENCE · PI PETERSON, BLAKE · 2017 to 2021
$1.7M
Increased Sensitivity of Minimal Residual Disease Monitoring using Peripheral Blood in Pediatric Patients with Acute Lymphoblastic LeukemiaR33CA235597 · NCI · UNIVERSITY OF KANSAS LAWRENCE · PI AUGUST, KEITH, SOPER, STEVEN ALLAN · 2019 to 2022
$906k
NCI NIH HHS P30 CA168524NCI NIH HHS R01 CA211720NCI NIH HHS R33 CA235597NIBIB NIH HHS P41 EB020594NIGMS NIH HHS P20 GM103638NIGMS NIH HHS P20 GM130423
6 · The paper itself

Abstract

We detail a heterobifunctional, 7-aminocoumarin photocleavable (PC) linker with unique properties to covalently attach Abs to surfaces and subsequently release them with visible light (400-450 nm). The PC linker allowed rapid (2 min) and efficient (>90%) release of CTCs and EVs without damaging their molecular cargo.

Indexed as

Extracellular VesiclesNeoplastic Cells, CirculatingAntibodies, MonoclonalCell Line, TumorCell SurvivalCoumarinsHumansLightLiquid BiopsyMicrofluidicsAntibodies, MonoclonalCoumarins

Identifiers

PMID32163053
PMCPMC7469076

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.