Evidence map›Paper›PMID 32163000›Full record

ArticleBioengineered2020

Expression of chromogranin A-derived antifungal peptide CGA-N12 in

Xiaohua Li, Yong Fan, Qiong Lin, Jianxiong Luo, Yide Huang, Yuwang Bao, Liyu Xu

Open access · goldAbstract read
In one paragraph

Article in Bioengineered, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Engineering small peptide secretion inFrontiers in bioengineering and biotechnology · 2026
    Article
  4. Article
  5. Article
  6. Inhibition ofBioengineered · 2022
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Xiaohua LiDepartment of Respiratory Medicine, Affiliated Fuzhou First Hospital of Fujian Medical University, Fuzhou, Fujian, China.
Yong FanCentral Laboratory, Affiliated Fuzhou First Hospital of Fujian Medical University, Fuzhou, Fujian, China.
Qiong LinDepartment of Respiratory Medicine, Affiliated Fuzhou First Hospital of Fujian Medical University, Fuzhou, Fujian, China.
Jianxiong LuoDepartment of Respiratory Medicine, Affiliated Fuzhou First Hospital of Fujian Medical University, Fuzhou, Fujian, China.
Yide HuangProvincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, College of Life Sciences, Fujian Normal University, Fuzhou, China.
Yuwang BaoDepartment of Respiratory Medicine, Affiliated Fuzhou First Hospital of Fujian Medical University, Fuzhou, Fujian, China.
Liyu XuDepartment of Respiratory Medicine, Affiliated Fuzhou First Hospital of Fujian Medical University, Fuzhou, Fujian, China.
Fujian Medical University · CNFujian Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human chromogranin A-derived peptide CGA-N12, which is composed of 12 amino acid residues with the sequence ALQGAKERAHQQ, showed strong antifungal activity and the least hemolytic activity in previous studies. However, synthetic peptides are relatively expensive to produce. Recombinant expression of peptides in the host cells, such as bacteria or yeast, can fastly provide cost-efficient products of peptides. Here, we developed an innovative system to produce CGA-N12 peptides in the yeast

Indexed as

Antifungal AgentsChromatography, High Pressure LiquidChromogranin ADipeptidyl-Peptidases and Tripeptidyl-PeptidasesGolgi ApparatusPrognosisProprotein ConvertasesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSaccharomycetalesAntifungal AgentsChromogranin ADipeptidyl-Peptidases and Tripeptidyl-PeptidasesKEX2 protein, S cerevisiaeProprotein ConvertasesSaccharomyces cerevisiae ProteinsSTE13 protein, S cerevisiaeantimicrobial peptideChromogranin A derived peptidePichia pastorisrecombinant expression

Identifiers

PMID32163000
PMCPMC7161563
OpenAlexW3012011060

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.