ReviewJournal of orthopaedic research : official publication of the Orthopaedic Research Society2020
Fracture risk assessment and clinical decision making for patients with metastatic bone disease.
Review in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Artificial intelligence for bone metastases: a systematic review and meta-analysis of diagnostic and prognostic performance.Frontiers in oncology · 2026Pooled it
- SEOR SBRT-SG stereotactic body radiation therapy consensus guidelines for non-spine bone metastasis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022Guideline
- Diagnostic accuracy of Mirels score, CT-based Structural Rigidity Analysis, and Finite Element Analysis for predicting impending femoral pathologic fractures in metastatic bone disease: a systematic review.Journal of bone oncology · 2026Review
- Interventional Radiology in the Treatment of Musculoskeletal Tumours.Current oncology (Toronto, Ont.) · 2026Review
- Cost-utility of focused ultrasound compared to radiotherapy for Dutch patients with uncomplicated non-spinal bone metastases.The European journal of health economics : HEPAC : health economics in prevention and care · 2026Article
- Cost-effectiveness analysis of a bone metastasis cancer board for skeletal-related events of breast cancer.Japanese journal of clinical oncology · 2026Article
- Femur Fracture Risk Assessment in Patients with Lytic Metastases Using CT-Based Finite Element Models and Bone Crack Simulations Technique.Annals of biomedical engineering · 2026Article
- Metastatic renal cell carcinoma: risk of rapid progression to pathological fractures and factors influencing post-treatment survival - a Swedish Nationwide cohort study.Journal of bone oncology · 2026Article
- Artificial Intelligence and Machine Learning in Bone Metastasis Management: A Narrative Review.Current oncology (Toronto, Ont.) · 2026Review
- Discrepancy between X-ray and CT assessment in the Mirels score for long bone metastasis.BMC musculoskeletal disorders · 2025Article
- The influence of stem length on perioperative complications following cemented hip arthroplasty in metastatic femoral disease: A systematic review.Journal of orthopaedics · 2025Review
- Evaluating risk factors for skeletal-related events among bone metastases from solid tumors.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2025Article
- Use of the IlluminOss Implant for Treating a Pathologic Humeral Fracture in a Patient with Renal Cell Carcinoma Metastasis: A Case Report.Journal of orthopaedic case reports · 2025Article
- Social determinants are associated with clinical presentation of acute pathological fracture in metastatic long-bone disease.Journal of bone oncology · 2025Article
- Programmed cell death protein 1 (PD-1) blockade regulates skeletal remodeling in a sex- and age-dependent manner.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Article
- Restoring mobility: roles of percutaneous consolidation for pelvic ring bone lesions-a multicenter study.European radiology · 2025Article
- Prognostic assessment of osteolytic lesions and mechanical properties of bones bearing breast cancer using neural network and finite element analysisMechanobiology in medicine · 2025Article
- Review of Bone Metastasis in Gynecologic Malignancies: Evaluation and Treatment.Current treatment options in oncology · 2025Review
- Modern Treatment of Skeletal Metastases: Multidisciplinarity and the Concept of Oligometastasis in the Recent Literature.Current oncology (Toronto, Ont.) · 2025Review
- Routine histopathological examination of femoral heads and incidental metastatic bone disease in hip arthroplasty.Acta orthopaedica et traumatologica turcica · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Metastatic breast, prostate, lung, and other cancers often affect bone, causing pain, increasing fracture risk, and decreasing function. Management of metastatic bone disease (MBD) is clinically challenging when there is potential but uncertain risk of pathological fracture. Management of MBD has become a major focus within orthopedic oncology with respect to fracture and impending fracture care. If impending skeletal-related events (SREs), particularly pathologic fracture, could be predicted, increasing evidence suggests that prophylactic surgical treatment improves patient outcomes. However, current fracture risk assessment and radiographic metrics do not have high accuracy and have not been combined with relevant patient survival tools. This review first explores the prevalence, incidence, and morbidity of MBD and associated SREs for different cancer types. Strengths and limitations of current fracture risk scoring systems for spinal stability and long bone fracture are highlighted. More recent computed tomography (CT)-based structural rigidity analysis (CTRA) and finite element (FE) analysis methods offer advantages of increased specificity (true negative rate), but are limited in availability. Other fracture prediction approaches including parametric response mapping and positron emission tomography/computed tomography measures show early promise. Substantial new information to inform clinical decision-making includes measures of survival, clinical benefits, and economic analysis of prophylactic treatment compared to after-fracture stabilization. Areas of future research include use of big data and machine learning to predict SREs, greater access and refinement of CTRA/FE approaches, combination of clinical survival prediction tools with radiographically based fracture risk assessment, and net benefit analysis for fracture risk assessment and prophylactic treatment.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.