ArticleThe Prostate2020
Screening for chronic prostatitis pathogens using high-throughput next-generation sequencing.
Article in The Prostate, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Urinary microbiota and prostatic diseases: the key for the lock? A systematic review.Prostate cancer and prostatic diseases · 2023Pooled it
- The impact of vasectomy on the seminal microbiome: possible implications and source of microbes.Human reproduction open · 2026Article
- Efficacy of Willow Herb (Antibiotics (Basel, Switzerland) · 2025Article
- The role of microbiota in the chronic prostatitis/chronic pelvis pain syndrome: a review.Frontiers in microbiology · 2025Review
- Causal effect of gut microbiota on the risk of prostatitis: a two-sample Mendelian randomization study.International urology and nephrology · 2024Article
- Effects of low-intensity pulsed ultrasound on the microorganisms of expressed prostatic secretion in patients with IIIB prostatitis.Scientific reports · 2024Article
- Research progress on the relationship between chronic prostatitis/chronic pelvic pain syndrome and the microbiota of the reproductive system.Frontiers in cellular and infection microbiology · 2024Review
- Genetic insights into gut microbiota and risk of prostatitis: a Mendelian randomization study.Frontiers in microbiology · 2024Article
- Gut microbiome in men with chronic prostatitis/chronic pelvic pain syndrome: profiling and its predictive significance.World journal of urology · 2023Article
- Human Male Genital Tract Microbiota.International journal of molecular sciences · 2023Review
- Prostate diseases and microbiome in the prostate, gut, and urine.Prostate international · 2022Review
- Antibiotic therapy of chronic bacterial prostatitis is more effective considering antibiotic susceptibility of all pathogens isolated.Investigative and clinical urology · 2022Observational
- Urinary Microbiota-Are We Ready for Prime Time? A Literature Review of Study Methods' Critical Steps in Avoiding Contamination and Minimizing Biased Results.Diagnostics (Basel, Switzerland) · 2020Review
- Screening for chronic prostatitis pathogens using high-throughput next-generation sequencing.The Prostate · 2020Article
- The effectiveness of tamsulosin hydrochloride with terazosin combination therapy for chronic prostatitis Type-III b.Pakistan journal of medical sciencesArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe pathogens responsible for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS; NIH category III) are not currently known. the present study utilized high-throughput next-generation sequencing to screen for potential pathogens associated with NIH category III CP (CP III).
methodsThis study included 33 patients with CP III and 30 healthy men, from which one sample each of urethral secretions and expressed prostatic secretion (EPS) was collected. High-throughput next-generation sequencing was performed to detect the sequence variations and the relative abundance of the bacterial 16S ribosomal variable region and fungal internal transcribed spacer region in all samples. Bioinformatics software and databases were used for data analysis, and differences with P < .05 were considered statistically significant.
resultsUnweighted pair group method with arithmetic mean (UPGMA) cluster analysis, principal component analysis (PCA), and Spearman's rank correlation showed that the microbial compositions of the urethral secretions and EPS collected from the same subject were essentially the same.
conclusionsNo potential pathogens were identified in diagnosed patients with CP III. The EPS may be free from bacteria before and after infection. Changes in the urinary tract microbiome may disrupt the microecological balance of the urinary system, thereby leading to CP III. Conversely, the true pathogens of CP III may not be prokaryotic or eukaryotic microorganisms, Future research may involve the evaluation of noncellular microbes.
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