ArticleSchizophrenia bulletin2020
A Neural Signature of Parkinsonism in Patients With Schizophrenia Spectrum Disorders: A Multimodal MRI Study Using Parallel ICA.
Article in Schizophrenia bulletin, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Structural covariance networks in schizophrenia: A systematic review Part I.Schizophrenia research · 2022Pooled it
- [The sensorimotor domain in the research domain criteria system: progress and perspectives].Der Nervenarzt · 2021Pooled it
- Concomitant pathologies and their impact on schizophrenia: a narrative overview of current evidence.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Aberrant fronto-limbic network in adolescents with attention-deficit/hyperactivity disorder: a multimodal MRI study using parallel ICA.European archives of psychiatry and clinical neuroscience · 2026Article
- Positive and negative falls short: why any attempt to rename schizophrenia must include careful consideration of the sensori-/psychomotor domain.European archives of psychiatry and clinical neuroscience · 2026Article
- Cerebellar structure is abnormal in schizophrenia and deviates from bipolar disorder.NeuroImage. Clinical · 2026Article
- Sensori- and psychomotor abnormalities, psychopathological symptoms and functionality in schizophrenia-spectrum disorders: a network analytic approach.Schizophrenia (Heidelberg, Germany) · 2025Article
- Links between brain structure and function in children with autism spectrum disorder by parallel independent component analysis.Brain imaging and behavior · 2025Article
- Structure-function interrelationships and associated neurotransmitter profiles in drug-naïve benign childhood epilepsy with central-temporal spikes patients.European radiology · 2025Article
- Structure/function interrelationships and illness insight in patients with schizophrenia: a multimodal MRI data fusion study.European archives of psychiatry and clinical neuroscience · 2023Article
- dcSBM: A federated constrained source-based morphometry approach for multivariate brain structure mapping.Human brain mapping · 2023Article
- Gray matter alterations in tremor-dominant Parkinson's disease after MRgFUS thalamotomy are correlated with tremor improvement: a pilot study.Quantitative imaging in medicine and surgery · 2023Article
- The Behavioral Mapping of Psychomotor Slowing in Psychosis Demonstrates Heterogeneity Among Patients Suggesting Distinct Pathobiology.Schizophrenia bulletin · 2023Article
- Characterizing the sensorimotor domain in schizophrenia spectrum disorders.European archives of psychiatry and clinical neuroscience · 2022Article
- RNA-seq analysis of gene expression profiles in posttraumatic stress disorder, Parkinson's disease and schizophrenia identifies roles for common and distinct biological pathways.Discover mental health · 2022Article
- Disentangling dyskinesia from parkinsonism in motor structures of patients with schizophrenia.Brain communications · 2022Article
- Between-sex variability of resting state functional brain networks in amyotrophic lateral sclerosis (ALS).Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Structural alterations in brainstem, basal ganglia and thalamus associated with parkinsonism in schizophrenia spectrum disorders.European archives of psychiatry and clinical neuroscience · 2021Article
- Why is there symptom coupling of psychological and motor changes in psychomotor mechanisms? Insights from the brain's topography.Molecular psychiatry · 2021Article
- Sensorimotor Neuroscience in Mental Disorders: Progress, Perspectives and Challenges.Schizophrenia bulletin · 2021Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Motor abnormalities in schizophrenia spectrum disorders (SSD) have increasingly attracted scientific interest in the past years. However, the neural mechanisms underlying parkinsonism in SSD are unclear. The present multimodal magnetic resonance imaging (MRI) study examined SSD patients with and without parkinsonism, as defined by a Simpson and Angus Scale (SAS) total score of ≥4 (SAS group, n = 22) or <4 (non-SAS group, n = 22). Parallel independent component analysis (p-ICA) was used to examine the covarying components among gray matter volume maps computed from structural MRI (sMRI) and fractional amplitude of low-frequency fluctuations (fALFF) maps computed from resting-state functional MRI (rs-fMRI) patient data. We found a significant correlation (P = .020, false discovery rate [FDR] corrected) between an sMRI component and an rs-fMRI component, which also significantly differed between the SAS and non-SAS group (P = .042, z = -2.04). The rs-fMRI component comprised the cortical sensorimotor network, and the sMRI component included predominantly a frontothalamic/cerebellar network. Across the patient sample, correlations adjusted for the Positive and Negative Syndrome Scale (PANSS) total scores showed a significant relationship between tremor score and loadings of the cortical sensorimotor network, as well as between glabella-salivation score, frontothalamic/cerebellar and cortical sensorimotor network loadings. These data provide novel insights into neural mechanisms of parkinsonism in SSD. Aberrant bottom-up modulation of cortical motor regions may account for these specific motor symptoms, at least in patients with SSD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.