Evidence map›Paper›PMID 32162603›Full record

ReviewToxicologic pathology2020

Neuroprotein Targets of γ-Diketone Metabolites of Aliphatic and Aromatic Solvents That Induce Central-Peripheral Axonopathy.

Peter S Spencer

Open access · bronzeAbstract readReview
In one paragraph

Review in Toxicologic pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Peter S SpencerOregon Institute of Occupational Health Sciences and Department of Neurology, School of Medicine, Oregon Health & Science University, Portland, OR, USA.ORCID 0000-0003-3994-2639
Oregon Health & Science University · US

Funding

NEUROTOXICOGENOMICS AND CHILD HEALTHU19ES011384 · NIEHS · OREGON HEALTH & SCIENCE UNIVERSITY · PI SPENCER, PETER S · 2001 to 2006
$8.7M
NIEHS NIH HHS U19 ES011384
6 · The paper itself

Abstract

Peripheral neuropathy associated with chronic occupational and deliberate overexposure to neurotoxic organic solvents results from axonal degeneration in the central and peripheral nervous system. Human and experimental studies show that axonopathy is triggered by the action of neuroprotein-reactive γ-diketone metabolites formed from exposure to certain aliphatic solvents (

Indexed as

AnimalsHexanesHumansNerve DegenerationNeuronsNeurotoxicity SyndromesOrganic ChemicalsSolventsHexanesn-hexaneOrganic ChemicalsSolvents1,2-diacetylbenzene; neuropathyaxonopathydiabetes mellituslysineneuroproteinsn-hexane

Identifiers

PMID32162603
PMCPMC7113121
OpenAlexW3010876820

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.