Evidence map›Paper›PMID 32162475›Full record

ArticleChemMedChem2020

Synthesis and Biological Evaluation of Hapten-Clicked Analogues of The Antigenic Peptide Melan-A/MART-1

Marion Tarbe, John J Miles, Emily S J Edwards, Kim M Miles, Andrew K Sewell, Brian M Baker, Stéphane Quideau

Open access · greenAbstract read
In one paragraph

Article in ChemMedChem, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 4 countries.

Marion TarbeUniversité de Bordeaux, ISM (CNRS-UMR 5255), 351 cours de la Libération, 33405, Talence Cedex, France.
John J MilesAustralian Institute of Tropical Health and Medicine, James Cook University, Cairns, QLD 4878, Australia.ORCID 0000-0001-5506-6304
Emily S J EdwardsDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff, CF14 4XN, UK.ORCID 0000-0002-0240-4370
Kim M MilesDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff, CF14 4XN, UK.
Andrew K SewellDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff, CF14 4XN, UK.ORCID 0000-0003-3194-3135
Brian M BakerDepartment of Chemistry & Biochemistry, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, IN 46556, USA.ORCID 0000-0002-0864-0964
Stéphane QuideauUniversité de Bordeaux, ISM (CNRS-UMR 5255), 351 cours de la Libération, 33405, Talence Cedex, France.ORCID 0000-0002-7079-9757
Cardiff University · GBCentre National de la Recherche Scientifique · FRAustralian Institute of Tropical Health and Medicine · AUMonash University · AUUniversity of Notre Dame · US

Funding

Structural biophysics and molecular design in cellular immunityR35GM118166 · NIGMS · UNIVERSITY OF NOTRE DAME · PI BAKER, BRIAN M · 2016 to 2025
$4.4M
Biotechnology and Biological Sciences Research Council BB/H001085/1NIGMS NIH HHS R35 GM118166
6 · The paper itself

Abstract

A click-chemistry-based approach was implemented to prepare peptidomimetics designed in silico and made from aromatic azides and a propargylated GIGI-mimicking platform derived from the altered Melan-A/MART-1

Indexed as

Click ChemistryHaptensHLA-A2 AntigenHumansMART-1 AntigenMolecular StructureOligopeptidesPeptidomimeticsReceptors, Antigen, T-CellHaptensHLA-A2 AntigenMART-1 AntigenOligopeptidesPeptidomimeticsReceptors, Antigen, T-Cellantigenic peptidomimeticsclick chemistryimmunotherapyorganic haptensT-cell receptor

Identifiers

PMID32162475
PMCPMC7473458
OpenAlexW3011040176

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.