ArticleAnnals of clinical and translational neurology2020
Brain metabolic alterations herald falls in patients with Parkinson's disease.
Article in Annals of clinical and translational neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Development and validation of a clinical prediction model for first fall in early Parkinson's disease: a study of two fall-naive cohorts.Frontiers in aging neuroscience · 2026Article
- Cortical connectivity is associated with cognition across time in Parkinson's disease.Neuroimage. Reports · 2025Article
- Metabolic Dysregulation in Parkinson's Disease: Non-Oxidative Phosphorylation and Its Role in Brain Energy Metabolism.Aging and disease · 2025Review
- Review
- Cortical networks of parkinsonian gait: a metabolic and functional connectivity study.Annals of clinical and translational neurology · 2024Article
- Positron emission tomography neuroimaging of [Frontiers in neuroscience · 2024Article
- Salience network and cognitive impairment in Parkinson's disease.medRxiv : the preprint server for health sciences · 2023Article
- A 3D atlas of functional human brain energetic connectome based on neuropil distribution.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Gait Initiation Impairment in Patients with Parkinson's Disease and Freezing of Gait.Bioengineering (Basel, Switzerland) · 2022Article
- Thalamic morphology predicts the onset of freezing of gait in Parkinson's disease.NPJ Parkinson's disease · 2021Article
- Gait initiation in progressive supranuclear palsy: brain metabolic correlates.NeuroImage. Clinical · 2020Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pathophysiological understanding of gait and balance disorders in Parkinson's disease is insufficient and late recognition of fall risk limits efficacious follow-up to prevent or delay falls. We show a distinctive reduction of glucose metabolism in the left posterior parietal cortex, with increased metabolic activity in the cerebellum, in parkinsonian patients 6-8 months before their first fall episode. Falls in Parkinson's disease may arise from altered cortical processing of body spatial orientation, possibly predicted by abnormal cortical metabolism.
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