Evidence map›Paper›PMID 32162348›Full record

ArticleHistopathology2020

Dermatopathic reaction of lymph nodes in HTLV-1 carriers: a spectrum of reactive and neoplastic lesions.

Shigeki Chinen, Takuya Miyagi, Yoshiya Murakami, Mitsuyoshi Takatori, Shugo Sakihama, Iwao Nakazato, Yoshiyuki Kariya, Sayaka Yamaguchi, Kenzo Takahashi, Kennosuke Karube

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Histopathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Shigeki ChinenFaculty of Medicine, University of the Ryukyus, Okinawa, Japan.
Takuya MiyagiDepartment of Dermatology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Yoshiya MurakamiFaculty of Medicine, University of the Ryukyus, Okinawa, Japan.
Mitsuyoshi TakatoriDepartment of Pathology and Cell Biology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Shugo SakihamaDepartment of Pathology and Cell Biology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Iwao NakazatoDepartment of Pathology, Okinawa Prefectural Nanbu Medical Center and Children's Medical Center, Okinawa, Japan.
Yoshiyuki KariyaDepartment of Dermatology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Sayaka YamaguchiDepartment of Dermatology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Kenzo TakahashiDepartment of Dermatology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Kennosuke KarubeDepartment of Pathology and Cell Biology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.ORCID https://orcid.org/0000-0002-1205-858X
University of the Ryukyus · JP

Funding

Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical CareJapan Leukemia Research FundMinistry of Education, Culture, Sports, Science and Technology of Japan Grants-in-aid for Scientific Research (KAKENHI) 1Mochida Memorial Foundation for Medical and Pharmaceutical ResearchOkinawa Internal Medicine Research Promotion SocietyOkinawa prefectureThe Japanese Society of Hematology Research GrantYasuda Memorial Medical Foundation
6 · The paper itself

Abstract

aimsDermatopathic reaction is a histopathological finding of lymph nodes that usually occurs in patients with inflammatory pruritic cutaneous lesions. However, it is sometimes seen in patients with cutaneous T cell lymphoma. Adult T cell leukaemia/lymphoma (ATLL) is a T cell malignancy caused by infection with human T cell leukaemia virus type I (HTLV-1), which is frequently accompanied by cutaneous lesions. However, the detailed clinicopathological characteristics of the dermatopathic reaction of lymph nodes in ATLL patients and HTLV-1 carriers, addressed in this study, remains to be clarified. METHODS AND

resultsWe retrospectively analysed 18 nodal lesions with dermatopathic reaction in HTLV-1 carriers. Axillary and inguinal lymph nodes were the primary affected tissues. Three cases with atypical lymphoid cell infiltration were defined as ATLL with dermatopathic reaction (ATLL-D), showing an abnormal T cell immunophenotype and T cell monoclonality. Two of the three ATLL-D patients died 14 and 7 months after diagnosis (the third case had a very short follow-up). The other 15 patients were indistinguishable from reactive lesions and were defined as HTLV-1-associated lymphadenitis with dermatopathic reaction (HAL-D). They showed an indolent clinical course, with only one case eventually transforming to aggressive disease.

conclusionsLymph node lesions accompanied by dermatopathic reaction in HTLV1 carriers represent a spectrum that includes reactive and neoplastic conditions. HAL-D should be distinguished from ATLL-D, especially to avoid overtreatment.

Indexed as

AgedFemaleHTLV-I InfectionsHumansHuman T-lymphotropic virus 1Leukemia-Lymphoma, Adult T-CellLymph NodesLymphoma, T-Cell, CutaneousMaleMiddle AgedRetrospective StudiesSkinSkin Neoplasmsadult T cell leukaemia/lymphomadermatopathic reactionhuman T cell leukaemia virus type 1immunophenotypeprognosis

Identifiers

PMID32162348
PMCPMC7383570
OpenAlexW3011481748

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.