Evidence map›Paper›PMID 32162270›Full record

ArticleEuropean journal of drug metabolism and pharmacokinetics2020

Pharmacokinetics of Polyethylene Glycol-Modified Canine Uricase Following Single and Multiple Intravenous Injections in Cynomolgus Monkeys.

Haigang Li, JingJing Huo, Dan Sun, Liang Jiang, Chunlan Hu, Yanmin Bai, Xuefeng Ma, Haijuan Zhang, Xiaowei Shi, Zhilong Zhao and 3 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in European journal of drug metabolism and pharmacokinetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Haigang LiCollege of Pharmacy, Linyi University, Linyi, 276000, Shandong, People's Republic of China.
JingJing HuoCollege of Pharmacy, Linyi University, Linyi, 276000, Shandong, People's Republic of China.
Dan SunRizhao Institute of Scientific and Technological Information, Shandong, People's Republic of China.
Liang JiangRenrui Biotechnology Inc., Shandong, People's Republic of China.
Chunlan HuFagen Biomedical Inc., Chongqing, People's Republic of China.
Yanmin BaiFagen Biomedical Inc., Chongqing, People's Republic of China.
Xuefeng MaFagen Biomedical Inc., Chongqing, People's Republic of China.
Haijuan ZhangCollege of Pharmacy, Linyi University, Linyi, 276000, Shandong, People's Republic of China.
Xiaowei ShiCollege of Pharmacy, Linyi University, Linyi, 276000, Shandong, People's Republic of China.
Zhilong ZhaoCollege of Pharmacy, Linyi University, Linyi, 276000, Shandong, People's Republic of China.
Jinchuan ZhouCollege of Pharmacy, Linyi University, Linyi, 276000, Shandong, People's Republic of China.
Yongxin LuSuzhou Drug Safety Evaluation and Research Center, Suzhou Xishan Zhongke Laboratory Animal Co., Ltd., Jiangsu, People's Republic of China.
Chun ZhangCollege of Pharmacy, Linyi University, Linyi, 276000, Shandong, People's Republic of China. zhangchun@lyu.edu.cn.
Linyi University · CNBeike Biotechnology (China) · CNInstitute of Scientific and Technical Information · CN

Funding

Rizhao science and technology innovation project 2019CXZX1205Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province (CN) J15LM11Specialized Research Fund for the Doctoral Program of Higher Education of China (CN) 2018GSF121017
6 · The paper itself

Abstract

BACKGROUND AND

objectivePolyethylene glycol-modified canine uricase (PEG-UHC) prepared with a lower-molecular-weight (5 kDa) PEG is used to treat gout. This study investigated the comparative pharmacokinetics of single and multiple doses of PEG-UHC administered intravenously and a single dose of uricase (UHC) administered intravenously in cynomolgus monkeys.

methodsA noncompartmental model was used to fit the plasma drug concentration-time curve and calculate the pharmacokinetic parameters of PEG-UHC, which were compared with those obtained for UHC at the equivalent dose (2 mg/kg). To study the pharmacokinetics after multiple dose administration, cynomolgus monkeys were administered five intravenous injections of PEG-UHC (0.5 mg/kg), with one injection performed every 15 days.

resultsThe area under the curve (AUC) and the maximum plasma concentration (C

conclusionOur data show that PEG-UHC is markedly superior to UHC in terms of duration of action, and that the pharmacokinetics of PEG-UHC in cynomolgus monkeys are linear. Sequential administration of PEG-UHC did not accelerate drug clearance. Our findings provide the basis for future clinical studies of PEG-UHC.

Indexed as

AnimalsDrug Administration ScheduleDrug CompoundingFemaleGout SuppressantsInjections, IntravenousMacaca fascicularisMaleModels, BiologicalPolyethylene GlycolsUrate OxidaseGout SuppressantsPegloticasePolyethylene GlycolsUrate Oxidase

Identifiers

PMID32162270
OpenAlexW3011147752

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.