ArticleEnvironmental science and pollution research international2020
Biosynthesized silver nanoparticles protect against hepatic injury induced by murine blood-stage malaria infection.
Article in Environmental science and pollution research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- The Pathology of the Brain Eating AmoebaIndian journal of microbiology · 2024Article
- The synergistic effect of Ficus carica nanoparticles and Praziquantel on mice infected by Schistosoma mansoni cercariae.Scientific reports · 2024Article
- Pharmacological Effects of Biosynthesis Silver Nanoparticles UtilizingInternational journal of nanomedicine · 2024Article
- Article
- Participation of Oxidative Stress in the Activity of Compounds Isolated fromMolecules (Basel, Switzerland) · 2023Article
- Green Synthesis of Silver Nanoparticles by the CyanobacteriaMarine drugs · 2022Article
- Exploring the Role of Antioxidants to Combat Oxidative Stress in Malaria Parasites.Current topics in medicinal chemistry · 2022Article
- Protective effects of silver nanoparticles in isoproterenol-induced myocardial infarction in rats.Frontiers in medicine · 2022Article
- Natural-Product-Based Solutions for Tropical Infectious Diseases.Clinical microbiology reviews · 2021Review
- Biosynthesized nanosilver as anti-oxidant, anti-apoptotic and anti-inflammatory agent againstSaudi journal of biological sciences · 2021Article
- Medicinal plants as a fight against murine blood-stage malaria.Saudi journal of biological sciences · 2021Review
- Biosynthesized silver nanoparticles regulate the iron status in the spleen of Plasmodium chabaudi-infected mice.Environmental science and pollution research international · 2020Article
- Silver Nanoparticles Biosynthesized WithFrontiers in veterinary science · 2020Article
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
Biosynthesized nanoparticles proposed to have antiplasmodial activities have attracted increasing attention for malaria that considered being one of the foremost hazardous diseases. In this study, Indigofera oblongifolia leaf extracts were used for the synthesis of silver nanoparticles (AgNPs), which were characterized utilizing transmission electron microscopy. We investigated the antiplasmodial and hepatoprotective effects of AgNPs against Plasmodium chabaudi-induced infection in mice. Treatment of the infected mice with 50 mg/kg AgNPs for seven days caused a significant decrease in parasitemia and reduced the histopatholoical changes in the liver, as indicated by Ishak's histology index. Further, the AgNPs alleviated the oxidative damage in the liver infected with P. chabaudi. This was evidenced by the changed levels of malondialdehyde, nitric oxide, and glutathione, as well as increased catalase activity after treatment with AgNPs. In addition, levels of the liver enzymes alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase were increased after treatment. Moreover, the findings showed the efficiency of AgNPs in improving the infected mice's erythrocyte counts and hemoglobin content. Generally, our results reported that AgNPs possess antiplasmodial and hepatoprotective properties.
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