Evidence map›Paper›PMID 32162209›Full record

ArticleGeroScience2020

Strain-specificity in the hydrogen sulphide signalling network following dietary restriction in recombinant inbred mice.

Stephen E Wilkie, Lorna Mulvey, William A Sands, Diana E Marcu, Roderick N Carter, Nicholas M Morton, Christopher Hine, James R Mitchell, Colin Selman

Abstract read
In one paragraph

Article in GeroScience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Targeting macro- and micro-nutrient regulation of HNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Stephen E WilkieGlasgow Ageing Research Network (GARNER), Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK.
Lorna MulveyGlasgow Ageing Research Network (GARNER), Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK.
William A SandsGlasgow Ageing Research Network (GARNER), Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK.
Diana E MarcuGlasgow Ageing Research Network (GARNER), Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK.
Roderick N CarterMolecular Metabolism Group, University/BHF Centre for Cardiovascular Sciences, Queens Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, UK.
Nicholas M MortonMolecular Metabolism Group, University/BHF Centre for Cardiovascular Sciences, Queens Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, UK.
Christopher HineDepartment of Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH, 44195, USA.
James R MitchellDepartment of Genetics and Complex Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
Colin SelmanGlasgow Ageing Research Network (GARNER), Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK. Colin.Selman@glasgow.ac.uk.ORCID 0000-0002-8727-0593

Funding

Requirement of hydrogen sulfide for the benefits of dietary sulfur amino acid restrictionR00AG050777 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI HINE, CHRISTOPHER MICHAEL · 2017 to 2019
$747k
Requirement of hydrogen sulfide for the benefits of dietary sulfur amino acid restrictionK99AG050777 · NIA · HARVARD SCHOOL OF PUBLIC HEALTH · PI HINE, CHRISTOPHER MICHAEL · 2015 to 2016
$257k
Medical Research Council MR/N013166/1NIA NIH HHS K99 AG050777NIA NIH HHS R00 AG050777Wellcome TrustWellcome Trust 100981/Z/13/ZWellcome Trust 213310/Z/18/Z
6 · The paper itself

Abstract

Modulation of the ageing process by dietary restriction (DR) across multiple taxa is well established. While the exact mechanism through which DR acts remains elusive, the gasotransmitter hydrogen sulphide (H

Indexed as

Caloric RestrictionHydrogen SulfideAnimalsFemaleLiverLongevityMiceMice, Inbred C57BLSignal TransductionHydrogen Sulfide3-mercaptopyruvate sulfurtransferaseAgeingCaloric restrictionDietary restrictionILSXISSLongevitySulphide

Identifiers

PMID32162209
PMCPMC7205779

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.