Evidence map›Paper›PMID 32162172›Full record

SynthesisCancer causes & control : CCC2020

Systematic review and meta-analysis of the associations between body mass index, prostate cancer, advanced prostate cancer, and prostate-specific antigen.

Sean Harrison, Kate Tilling, Emma L Turner, Richard M Martin, Rosie Lennon, J Athene Lane, Jenny L Donovan, Freddie C Hamdy, David E Neal, J L H Ruud Bosch and 1 more

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cancer causes & control : CCC, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 11 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 11 syntheses or guidelines pooled it, 85 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 2 countries.

Sean HarrisonDepartment of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, England. sean.harrison@bristol.ac.uk.
Kate TillingDepartment of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, England.
Emma L TurnerDepartment of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, England.
Richard M MartinDepartment of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, England.
Rosie LennonDepartment of Environment and Geography, University of York, York, England.
J Athene LaneDepartment of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, England.
Jenny L DonovanDepartment of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, England.
Freddie C HamdyNuffield Department of Surgical Sciences, University of Oxford, Oxford, England.
David E NealNuffield Department of Surgical Sciences, University of Oxford, Oxford, England.
J L H Ruud BoschDepartment of Urology, University Medical Centre Utrecht, Utrecht, The Netherlands.
Hayley E JonesDepartment of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, England.
University of Bristol · GBNational Institute for Health Research · GBAddenbrooke's Hospital · GBMedical Research Council · GBUniversity Hospitals Bristol NHS Foundation Trust · GBUniversity Medical Center Utrecht · NLUniversity of Oxford · GBUniversity of York · GB

Funding

Medical Research Council MR/M014533/1Wellcome Trust 102432/Z/13/Z
6 · The paper itself

Abstract

purposeThe relationship between body mass index (BMI) and prostate cancer remains unclear. However, there is an inverse association between BMI and prostate-specific antigen (PSA), used for prostate cancer screening. We conducted this review to estimate the associations between BMI and (1) prostate cancer, (2) advanced prostate cancer, and (3) PSA.

methodsWe searched PubMed and Embase for studies until 02 October 2017 and obtained individual participant data from four studies. In total, 78 studies were identified for the association between BMI and prostate cancer, 21 for BMI and advanced prostate cancer, and 35 for BMI and PSA. We performed random-effects meta-analysis of linear associations of log-PSA and prostate cancer with BMI and, to examine potential non-linearity, of associations between categories of BMI and each outcome.

resultsIn the meta-analyses with continuous BMI, a 5 kg/m

conclusionThere is little or no evidence of an association between BMI and risk of prostate cancer or advanced prostate cancer, and strong evidence of an inverse and non-linear association between BMI and PSA. The association between BMI and prostate cancer is likely biased if missed diagnoses are not considered.

Indexed as

Body Mass IndexEarly Detection of CancerHumansKallikreinsMaleObesityOverweightProstate-Specific AntigenProstatic NeoplasmsKallikreinsKLK3 protein, humanProstate-Specific AntigenBody mass indexMeta-analysisProstate cancerProstate-specific antigenScreeningSystematic review

Identifiers

PMID32162172
PMCPMC7105428
OpenAlexW3010969208

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.