ArticleCell and tissue banking2020
Preliminary studies of hair follicle regeneration by injections of epidermal stem cells and dermal papilla cells into nude mice.
Article in Cell and tissue banking, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Alkaline Phosphatase-Regulated C-C Motif Chemokine Ligand 5 (CCL5) Functions as a Critical Mediator of Hair Follicle Neogenesis.Tissue engineering and regenerative medicine · 2026Article
- Hair follicle regeneration technology: from microenvironment regulation to functional reconstruction.Frontiers in bioengineering and biotechnology · 2026Review
- Emerging biomedical engineering strategies for hair follicle regeneration.Bioactive materials · 2025Review
- Exosomes from human umbilical cord mesenchymal stem cells promote the growth of human hair dermal papilla cells.PloS one · 2025Article
- Hair Regeneration Methods Using Cells Derived from Human Hair Follicles and Challenges to Overcome.Cells · 2024Review
- Exosomes derived from mouse vibrissa dermal papilla cells promote hair follicle regeneration during wound healing by activating Wnt/β-catenin signaling pathway.Journal of nanobiotechnology · 2024Article
- Isolation, characterization and differentiation of dermal papilla cells from Small-tail Han sheep.Animal biotechnology · 2023Article
- Cell Therapy for Androgenetic Alopecia: Elixir or Trick?Stem cell reviews and reports · 2023Review
- Cells, growth factors and biomaterials used in tissue engineering for hair follicles regeneration.Regenerative therapy · 2022Review
- Hair Follicle Morphogenesis During Embryogenesis, Neogenesis, and Organogenesis.Frontiers in cell and developmental biology · 2022Review
- Functional hair follicle regeneration: an updated review.Signal transduction and targeted therapy · 2021Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The ultimate goal of organ regenerative therapy is to reproduce fully functional organs to replace which have been damaged as a result of diseases or injury. Although several studies claimed that using different types of cells in some animal models promote hair follicles regeneration, more researches can be done to develop a sufficient and efficient protocol to induce hair generation from different animal models. In this study, we investigated the therapeutic potentials for hair follicle formation by injecting a mixture of epidermal stem cells and dermal papilla cells. Those cells were isolated and culture-expanded. Then we randomly allocated 8 nude mice into two groups. The experiment group received an injection of a mixture that containing of epidermal stem cells and dermal papilla cells. The control group received injection of keratinocyte serum-free medium. The hair follicles regeneration was observed and the injection area was harvested for HE staining. 14 day later, the regenerated hair shafts were observed and HE staining indicated that the newly hair follicle formed the correct structures in experiment group. Furthermore, the mixture injection induced a regular and multilayered stratified epidermis and the epidermis contained of hair follicle-likes structures. Our data showed that injection of a mixture of epidermal stem cells and dermal papilla cells could induce hair follicles regeneration and well-ordered epidermis formation. This study emphasized that the rearrangement of the interactions during seed cells and the niches of the seed cells is essential and necessary for tissue-engineered construct success.
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Registered trials
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