Evidence map›Paper›PMID 32162160›Full record

ArticleAMB Express2020

Biosynthesis of uniformly carbon isotope-labeled docosahexaenoic acid in Crypthecodinium cohnii.

Pingping Song, Alexander Kuryatov, Paul H Axelsen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AMB Express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Production ofFrontiers in bioengineering and biotechnology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Pingping SongSchool of Biological Engineering, Guizhou Medical University, Guiyang, 550025, Guizhou, China. songqian70@163.com.ORCID http://orcid.org/0000-0002-3732-4776
Alexander KuryatovDepartment of Pharmacology, Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Paul H AxelsenDepartment of Pharmacology, Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, 19104, USA.
University of Pennsylvania · USGuiyang Medical University · CN

Funding

Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Rebecca A Simmons · 2006 to 2026
$35.3M
Posttranslational Protein Modification in Alzheimer PathologyRF1AG057197 · NIA · UNIVERSITY OF PENNSYLVANIA · PI AXELSEN, PAUL H · 2018 to 2018
$2.0M
NIA NIH HHS RF1 AG057197NIEHS NIH HHS P30 ES013508NIH HHS AG057197
6 · The paper itself

Abstract

Docosahexaenoic acid (DHA) enriched in brain can yield many important degradation products after the attack of hydroxyl radicals, which is known to serve as a nutraceutical and neuroprotective effects. Oxidative stress is a commonly observed feature of Alzheimer's disease (AD). Therefore, uniformly radiolabeled DHA plays an important role in studying the oxidative fate of DHA in vivo and vitro. However, carbon isotope labeled DHA isn't commercially available now. The heterotrophic microalgae Crypthecodinium cohnii (C. cohnii) has been identified as a prolific producer of DHA. In this study, the growth rate and DHA production in C. cohnii were optimized in a new defined media, and the biosynthesis of U-

Indexed as

Carbon isotope labelingCrypthecodinium cohniiDocosahexaenoic acidOxidative stressω-3 polyunsaturated fatty acids

Identifiers

PMID32162160
PMCPMC7065296
OpenAlexW3011126627

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.