ArticleMetabolomics : Official journal of the Metabolomic Society2020
Longitudinal analysis of the salivary metabolome of breast-fed and formula-fed infants over the first year of life.
Article in Metabolomics : Official journal of the Metabolomic Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- Advancements and Challenges in Salivary Metabolomics for Early Detection and Monitoring of Systemic Diseases.MedComm · 2025Review
- NMR-Based Metabolomics Demonstrates a Metabolic Change during Early Developmental Stages from Healthy Infants to Young Children.Metabolites · 2023Article
- Plasma lipids and growth faltering: A longitudinal cohort study in rural Gambian children.Science advances · 2021Article
- Evaluation of Saliva Stability for NMR Metabolomics: Collection and Handling Protocols.Metabolites · 2020Article
- Salivary metabolite levels in perinatally HIV-infected youth with periodontal disease.Metabolomics : Official journal of the Metabolomic Society · 2020Observational
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe salivary metabolome has been increasingly studied over the past ten years due to the potential of saliva as a non-invasive source of biomarkers. However, although saliva has been studied in relation to various diseases, its dynamic evolution during life is not known. This is particularly true for the first months of life. Infancy is indeed a critical period during which numerous behavioural and physiological events occur, such as dietary transitions and tooth eruption, which can lead to important biological modifications in the oral cavity.
objectivesThe aim of this work was therefore to study the evolution of the salivary metabolome during the first months of life by
methodsSaliva of 32 infants with different milk feeding histories (breast vs formula) was collected at 6 stages, including 3 months old, 15 days before the onset of complementary feeding (CF), approximately 15 days after the onset of CF, approximately 21 days after the onset of CF and at approximately 11 and 15 months, and analysed.
resultsThe longitudinal analysis showed a significant modification of the profiles of 18 metabolites over time; 14 presented an increase in abundance whereas 4 presented a decrease. These modifications seemed to be linked, for the most part, to an increase in oral microbial metabolism. Milk feeding history during the first months of life had no effect on metabolites.
conclusionThis work shows that the salivary metabolome should be considered when studying the changes occurring during infancy.
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