Evidence map›Paper›PMID 32162080›Full record

ArticlePediatric radiology2020

Lung T1 mapping magnetic resonance imaging in the assessment of pulmonary disease in children with cystic fibrosis: a pilot study.

Fatima Neemuchwala, Maryam Ghadimi Mahani, Yuxi Pang, Eunjee Lee, Timothy D Johnson, Craig J Galbán, Aleksa B Fortuna, Ramon Sanchez-Jacob, Chris A Flask, Samya Z Nasr

Abstract read
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In one paragraph

Article in Pediatric radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Longitudinal relaxation rate (Magma (New York, N.Y.) · 2025
    Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Bias field correction in hyperpolarizedMagnetic resonance in medicine · 2022
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Fatima NeemuchwalaDivision of Pediatric Pulmonology, Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
Maryam Ghadimi MahaniSection of Pediatric Radiology, C. S. Mott Children's Hospital, Department of Radiology, University of Michigan, 1540 E. Hospital Drive, SPC 4252, Ann Arbor, MI, 48109, USA. maryamg@umich.edu.ORCID 0000-0001-6451-2257
Yuxi PangDepartment of Radiology, University of Michigan, Ann Arbor, MI, USA.
Eunjee LeeDepartment of Information and Statistics, Chungnam National University, Daejeon, Republic of Korea.
Timothy D JohnsonDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Craig J GalbánDepartment of Radiology, University of Michigan, Ann Arbor, MI, USA.
Aleksa B FortunaDepartment of Radiology, University of Michigan, Ann Arbor, MI, USA.
Ramon Sanchez-JacobDepartment of Radiology, George Washington University Medical Center, Children's National Health System, Washington, DC, USA.
Chris A FlaskDepartments of Radiology, Biomedical Engineering, and Pediatrics, Case Western Reserve University, Cleveland, OH, USA.
Samya Z NasrDivision of Pediatric Pulmonology, C. S. Mott Children's Hospital, Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA.
University of Michigan · USCase Western Reserve University · USChildren's National · USChungnam National University · KRUniversity of California, San Francisco · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAssessment tools for early cystic fibrosis (CF) lung disease are limited. Detecting early pulmonary disease is crucial to increasing life expectancy by starting interventions to slow the progression of the pulmonary disease with the many treatment options available.

objectiveTo compare the utility of lung T1-mapping MRI with ultrashort echo time (UTE) MRI in children with cystic fibrosis in detecting early stage lung disease and monitoring pulmonary exacerbations. MATERIALS AND

methodsWe performed a prospective study in 16 children between September 2017 and January 2018. In Phase 1, we compared five CF patients with normal spirometry (mean 11.2 years) to five age- and gender-matched healthy volunteers. In Phase 2, we longitudinally evaluated six CF patients (median 11 years) in acute pulmonary exacerbation. All children had non-contrast lung T1-mapping and UTE MRI and spirometry testing. We compared the mean normalized T1 value and percentage lung volume without T1 value in CF patients and healthy subjects in Phase 1 and during treatment in Phase 2. We also performed cystic fibrosis MRI scoring. We evaluated differences in continuous variables using standard statistical tests.

resultsIn Phase 1, mean normalized T1 values of the lung were significantly lower in CF patients in comparison to healthy controls (P=0.02) except in the right lower lobe (P=0.29). The percentage lung volume without T1 value was also significantly higher in CF patients (P=0.006). UTE MRI showed no significant differences between CF patients and healthy volunteers (P=0.11). In Phase 2, excluding one outlier case who developed systemic disease in the course of treatment, the whole-lung T1 value increased (P=0.001) and perfusion scoring improved (P=0.02) following therapy. We observed no other significant changes in the MRI scoring.

conclusionLung T1-mapping MRI can detect early regional pulmonary CF disease in children and might be helpful in the assessment of acute pulmonary exacerbations.

Indexed as

AdolescentCase-Control StudiesChildCross-Sectional StudiesCystic FibrosisDisease ProgressionFemaleHumansLung DiseasesMagnetic Resonance ImagingMalePilot ProjectsProspective StudiesRespiratory Function TestsChildrenCystic fibrosisLungMagnetic resonance imagingPulmonary diseaseT1 mappingUltrashort echo time

Identifiers

PMID32162080
OpenAlexW3010971703

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.