Evidence map›Paper›PMID 32161996›Full record

ArticleWorld journal of urology2020

The role of fatal family history and mode of inheritance in prostate cancer for long-term outcomes following radical prostatectomy.

Valentin H Meissner, Jamila G H Strüh, Martina Kron, Lea A Liesenfeld, Stephanie Kranz, Jürgen E Gschwend, Kathleen Herkommer

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of urology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Loneliness in prostate cancer survivors.Journal of cancer research and clinical oncology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Valentin H MeissnerTechnical University of Munich, School of Medicine, Klinikum rechts der Isar, Department of Urology, Munich, Germany.
Jamila G H StrühTechnical University of Munich, School of Medicine, Klinikum rechts der Isar, Department of Urology, Munich, Germany.
Martina KronInstitute of Epidemiology and Medical Biometrics, University of Ulm, Ulm, Germany.
Lea A LiesenfeldTechnical University of Munich, School of Medicine, Klinikum rechts der Isar, Department of Urology, Munich, Germany.
Stephanie KranzTechnical University of Munich, School of Medicine, Klinikum rechts der Isar, Department of Urology, Munich, Germany.
Jürgen E GschwendTechnical University of Munich, School of Medicine, Klinikum rechts der Isar, Department of Urology, Munich, Germany.
Kathleen HerkommerTechnical University of Munich, School of Medicine, Klinikum rechts der Isar, Department of Urology, Munich, Germany. kathleen.herkommer@tum.de.ORCID http://orcid.org/0000-0002-0339-3394
TUM Klinikum · DEUniversität Ulm · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine whether fatal family history (FFH) or mode of inheritance in prostate cancer (PCa) has an impact on long-term outcomes following radical prostatectomy (RP).

methods1076 PCa patients after RP with at least one deceased first-degree relative with PCa were included and stratified by FFH (four subgroups: fraternal, paternal, multiple, and none) and by mode of inheritance (two subgroups: male to male, non-male to male). We compared clinicopathological characteristics between subgroups with Fisher's exact or Chi-square tests. Biochemical recurrence-free survival (BRFS) and cancer-specific survival (CSS) were analyzed using the method of Kaplan and Meier. Simple and multiple Cox regression with backward elimination were performed to select prognostic factors for BRFS and CSS.

resultsMedian age at surgery was 63.3 (range 35.9-79.4) years. The overall Kaplan-Meier estimated BRFS rate at 10 and 15 years was 65.6% and 57.0%, respectively. The overall Kaplan-Meier estimated CSS rate at 10 and 15 years was 98.1% and 95.7%, respectively. Neither FFH nor mode of inheritance were factors associated with worse BRFS. However, in multiple Cox regression, paternal FFH was an important prognostic factor for a better CSS (HR 0.19, CI 0.05-0.71, p = 0.014) compared to non-FFH.

conclusionFFH and mode of inheritance do not seem to be prognostic factors of worse long-term outcomes following RP. Rather, a paternal FFH was associated with a better CSS; however, the reasons remain unclear. Nevertheless, patients after RP and FFH could be reassured that their own PCa diagnosis is not associated with a worse long-term outcome.

Indexed as

Inheritance PatternsProstatectomyAdultAgedHumansMaleMedical History TakingMiddle AgedProstatic NeoplasmsRetrospective StudiesTime FactorsTreatment OutcomeBiochemical recurrence-free survivalCancer-specific survivalFatal family historyMode of inheritanceProstatic neoplasmsRadical prostatectomy

Identifiers

PMID32161996
PMCPMC7716855
OpenAlexW3011083888

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.